Search engine for discovering works of Art, research articles, and books related to Art and Culture
Javascript must be enabled to continue!
Impaired Arterial Smooth Muscle Cell Vasodilatory Function In Methamphetamine Users
View through CrossRef
Objectives: Methamphetamine use is a strong risk factor for stroke. This study was designed to evaluate arterial function and structure in methamphetamine users ultrasonographically.Methods: In a cross-sectional study, 20 methamphetamine users and 21 controls, aged between 20 and 40years, were enrolled. Common carotid artery intima-media thickness (CCA-IMT) marker of early atherogenesis, flow-mediated dilatation (FMD) determinants of endothelium-dependent vasodilation, and nitroglycerine-mediated dilatation (NMD) independent marker of vasodilation were measured in two groups.Results: There were no significant differences between the two groups regarding demographic and metabolic characteristics. The mean (±SD) CCA-IMT in methamphetamine users was 0.58±0.09mm, versus 0.59±0.07mm in the controls (p=0.84). Likewise, FMD% was not significantly different between the two groups [7.6±6.1% in methamphetamine users vs. 8.2±5.1% in the controls; p=0.72], nor were peak flow and shear rate after hyperemia. However, NMD% was considerably decreased in the methamphetamine users [8.5±7.8% in methamphetamine users vs. 13.4±6.2% in controls; p=0.03].Conclusion: According to our results, NMD is reduced among otherwise healthy methamphetamine users, which represents smooth muscle dysfunction in this group. This may contribute to the high risk of stroke among methamphetamine users.
Australian International Academic Centre
Title: Impaired Arterial Smooth Muscle Cell Vasodilatory Function In Methamphetamine Users
Description:
Objectives: Methamphetamine use is a strong risk factor for stroke.
This study was designed to evaluate arterial function and structure in methamphetamine users ultrasonographically.
Methods: In a cross-sectional study, 20 methamphetamine users and 21 controls, aged between 20 and 40years, were enrolled.
Common carotid artery intima-media thickness (CCA-IMT) marker of early atherogenesis, flow-mediated dilatation (FMD) determinants of endothelium-dependent vasodilation, and nitroglycerine-mediated dilatation (NMD) independent marker of vasodilation were measured in two groups.
Results: There were no significant differences between the two groups regarding demographic and metabolic characteristics.
The mean (±SD) CCA-IMT in methamphetamine users was 0.
58±0.
09mm, versus 0.
59±0.
07mm in the controls (p=0.
84).
Likewise, FMD% was not significantly different between the two groups [7.
6±6.
1% in methamphetamine users vs.
8.
2±5.
1% in the controls; p=0.
72], nor were peak flow and shear rate after hyperemia.
However, NMD% was considerably decreased in the methamphetamine users [8.
5±7.
8% in methamphetamine users vs.
13.
4±6.
2% in controls; p=0.
03].
Conclusion: According to our results, NMD is reduced among otherwise healthy methamphetamine users, which represents smooth muscle dysfunction in this group.
This may contribute to the high risk of stroke among methamphetamine users.
.
Related Results
Poster 247: Muscle ERRγ Overexpression Mitigates the Muscle Atrophy after ACL injury
Poster 247: Muscle ERRγ Overexpression Mitigates the Muscle Atrophy after ACL injury
Objectives:
Anterior cruciate ligament (ACL) reconstruction is the 6th most common orthopedic procedure performed in the United States (1,2). There is substanti...
Comparison of Psychiatric Disorders in a Sample of Egyptian Patients with Methamphetamine versus Opioid Use Disorder: Rate and Addiction Severity
Comparison of Psychiatric Disorders in a Sample of Egyptian Patients with Methamphetamine versus Opioid Use Disorder: Rate and Addiction Severity
Abstract
Background
Methamphetamine use is markedly increasing worldwide. That widespread isn’t limited to high income countries...
Gray-matter structure in long-term abstinent methamphetamine users
Gray-matter structure in long-term abstinent methamphetamine users
Abstract
Background
Previous studies of brain structure in methamphetamine users have yielded inconsistent findings, possibly reflecting small sampl...
Lists, Spatial Practice and Assistive Technologies for the Blind
Lists, Spatial Practice and Assistive Technologies for the Blind
IntroductionSupermarkets are functionally challenging environments for people with vision impairments. A supermarket is likely to house an average of 45,000 products in a median fl...
Abstract 14196: Methamphetamine Use is Associated With Increased In-Hospital Mortality After Aortic Dissection: The National Inpatient Sample Perspective
Abstract 14196: Methamphetamine Use is Associated With Increased In-Hospital Mortality After Aortic Dissection: The National Inpatient Sample Perspective
Introduction:
Aortic dissection is a rare complication associated with methamphetamine abuse. Mortality in aortic dissection is high, however outcomes in methamphetamin...
The relationship between Agouti related protein and leptin in patients with methamphetamine use disorder
The relationship between Agouti related protein and leptin in patients with methamphetamine use disorder
Abstract
Background
Appetite regulation involves a complex interplay between peripheral signals and central hypothalamic neuropeptides. Two key h...
Elevated Monocyte Chemoattractant Protein-1 and Nuclear Factor Kappa B Biomarkers in Captagon and Methamphetamine Addiction
Elevated Monocyte Chemoattractant Protein-1 and Nuclear Factor Kappa B Biomarkers in Captagon and Methamphetamine Addiction
Background: Addiction is a complex, chronic brain disorder characterized by compulsive drug seeking and use despite harmful consequences. They affect approximately 10% of the popul...
Mitochondrial Function Influences Expression of Methamphetamine-Induced Motor Sensitization
Mitochondrial Function Influences Expression of Methamphetamine-Induced Motor Sensitization
Abstract
Repeated methamphetamine use leads to neuronal maladaptations resulting in addictions. Mechanisms that underpin such adaptations have high energy requirements, imp...