CHANGES IN HEMATOLOGICAL AND BIOCHEMICAL PARAMETERS OF NUTRIA DURING EXPERIMENTAL TRICHINELLOSIS

To date, the pathogenesis of trichinellosis in nutria remains incompletely characterized. A comprehensive analysis of morphological and biochemical blood parameter alterations in infected animals has not previously been conducted. This knowledge gap has significantly impeded the establishment of reliable diagnostic criteria and effective disease monitoring protocols for application in fur-farming operations. The present study investigates the clinical manifestations and objective changes in blood parameters of nutria affected by trichinellosis resulting from infection with Trichinella spiralis larvae. The experiment was performed on a cohort of five nutria, with an infection dose of 3000 larvae per animal. During the observational period, infected animals exhibited a range of symptom complexes indicative of dysfunction in multiple physiological systems, including the digestive, respiratory, cardiovascular, and nervous systems. To monitor dynamic changes in blood parameters, blood samples were collected at predefined time points: on days 5, 10, 15, and 25 post-infection. Analysis revealed that Trichinella spiralis larvae exert both traumatic and toxic effects on various organs and tissues. These effects likely contribute to the observed systemic disturbances. The findings of this study substantially deepen the understanding of trichinellosis pathogenesis in nutria. Furthermore, they provide a robust scientific foundation for the development of evidence-based diagnostic criteria and targeted prevention strategies applicable to fur-farming environments.