Pharmacokinetics Of Chitosan-Ethacridine Adduct In Rats

The objective of this study is to investigate the pharmacokinetics of the chitosan-ethacridine adduct in white rats. It was demonstrated that the kinetics of ethacridine release from adduct are significantly different from that for intraperitoneally introduced ethacridine. When free ethacridine was introduced, 80% of the administered amount was detected in blood of rats in 30 min. This quantity decreased gradually until 20 h, when 1.25% of the administered amount was detected. Contrary, for chitosan-ethacridine adduct, the ethacridine content in the blood slowly increased for 8 h and then decreased. Even after 72 h of the injection, 3% of the injected amount of ethacridine was detected. The experiment demonstrates a significant delay in the release of ethacridine from the chitosan-ethacridine adduct in the blood of treated rats. Thus, a possibility of using chitosan for prolongation of action of the ethacridine as an antiseptic agent was shown.