THE INFLUENCE OF HELICOBACTER PYLORI ON THE DEVELOPMENT OF PANCREAS AND LIVER DISEASE

Objective of the study: the aim of our study was to determine the state of the liver and pancreas according to the activity of their enzymes and ultrasound diagnostics in patients with gastric ulcer and duodenal ulcer in chronic helicobacter pylori. Materials and methods of the study: we examined 45 patients (21 men and 24 women) with Helicobacter pylori (Hр)-associated gastric ulcer and / or duodenal ulcer and 20 relatively healthy individuals who formed the control group. The diagnosis of ulcerative and destructive gastric lesions and duodenal ulcers was confirmed endoscopically, and Hp-infection was proved by urease, microbiological and histological tests. All patients in the main group were infected with Hр. Biochemical blood tests were performed at the initial stage of the examination before eradication therapy. Patients referred for blood biochemical testing had not taken eradication therapy within the last 6 months. Results of the study: in a comprehensive examination of patients with gastric ulcer and/or duodenal ulcer on the background of chronic Hp-infection, the dominance of such complaints as abdominal pain, feeling of heaviness, distension in the epigastric region, nausea, heartburn, sour belching, and bowel movements disorder (in the form of constipation or diarrhea) was established. The results of biochemical blood tests revealed signs of cholestasis, cytolysis of hepatocytes and pancreatic acinar cells in patients with gastric ulcer and / or duodenal ulcers against the background of chronic helicobacteriosis. Ultrasound examination of the abdominal cavity revealed the prevalence of fatty infiltration of the liver, diffuse parenchymal changes in the liver and pancreas, compaction, thickening of the gallbladder walls, and the presence of calculi in the gallbladder compared to controls. Conclusions: the results of the study confirm the frequent comorbid liver and pancreas lesions in the setting of Hp-associated gastric ulcer and / or duodenal ulcer, which requires the mandatory inclusion of abdominal ultrasound in the scheme of comprehensive examination of patients.