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A review of polydactyly and its inheritance: Connecting the dots
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Objective:
This study collects what is known about the inheritance underpinnings of syndromic and non-syndromic polydactylies and highlights dactyly presentations with unknown genetic roots. This review summarizes the current information and genetics-enhanced understanding of polydactyly.
Background:
There is a frequency of 0.37 to 1.2 per 1000 live births for polydactyly, which is also known as hyperdactyly. It is characterized by the presence of extra fingers. Polydactyly is caused by a failure in limb development, specifically the patterning of the developing limb bud. The phenotypic and genetic variability of polydactyly makes its etiology difficult to understand. Pre-axial polydactyly, central polydactyly (axial), and postaxial polydactyly are all examples of non-syndromic polydactyly (ulnar). An autosomal dominant disorder with varying penetrance that is mostly passed down via limb development patterning abnormalities.
Method:
A comprehensive search of MEDLINE/PubMed and other databases was followed by an evaluation of the relevant papers, with a particular focus on those published between 2000 and 2022.
Results:
Of 747 published article related to Polydactyly from MEDLINE/PubMed search, 43 were from the last 10 years and were the focus of this review.
Conclusion:
Polydactyly is one of the most frequent congenital hand malformations. PAP is more common than PPD, whereas central polydactyly is very uncommon.
Title: A review of polydactyly and its inheritance: Connecting the dots
Description:
Objective:
This study collects what is known about the inheritance underpinnings of syndromic and non-syndromic polydactylies and highlights dactyly presentations with unknown genetic roots.
This review summarizes the current information and genetics-enhanced understanding of polydactyly.
Background:
There is a frequency of 0.
37 to 1.
2 per 1000 live births for polydactyly, which is also known as hyperdactyly.
It is characterized by the presence of extra fingers.
Polydactyly is caused by a failure in limb development, specifically the patterning of the developing limb bud.
The phenotypic and genetic variability of polydactyly makes its etiology difficult to understand.
Pre-axial polydactyly, central polydactyly (axial), and postaxial polydactyly are all examples of non-syndromic polydactyly (ulnar).
An autosomal dominant disorder with varying penetrance that is mostly passed down via limb development patterning abnormalities.
Method:
A comprehensive search of MEDLINE/PubMed and other databases was followed by an evaluation of the relevant papers, with a particular focus on those published between 2000 and 2022.
Results:
Of 747 published article related to Polydactyly from MEDLINE/PubMed search, 43 were from the last 10 years and were the focus of this review.
Conclusion:
Polydactyly is one of the most frequent congenital hand malformations.
PAP is more common than PPD, whereas central polydactyly is very uncommon.
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