Hemostatic and hemodynamic effects of two different doses of epinephrine during endoscopic sinus surgery: A randomized controlled trial.

Objective: To determine the hemostatic and hemodynamic effects of two different doses of epinephrine during endoscopic sinus surgery. Study Design: Randomized Control Trial. Setting: Department of Otolaryngology, Teaching Hospital, D. G. Khan Medical College, Dera Ghazi Khan. Period: 1st January, 2020 to 31st December, 2020. Material & Methods: A randomized control trail was done at ENT Department, Teaching Hospital Dera Ghazi Khan. 96 subjects were included and divided into two groups. Group-A patients received lidocaine hydrochloride, 2%, with 1:100,000 epinephrine while group-B patients received lidocaine, 2%, with 1:200,000 epinephrine. Data were collected through a structured proforma and analyzed using SPSS version 22.0. Numerical variables presented as mean and standard deviation and qualitative variables as frequency and percentages were calculated. Independent sample t test was used to compare the quantitative variables between both groups. Chi-square test was used to estimate the association between qualitative variables. P-value <0.05 was considered significant. Results: Among 30 patients of Group-A, 60.4% were males, mean age was 39.73+10.736 years and the mean blood loss was 202.58+12.218 ml. In Group-B, 64.6% were males, mean age was 39.35+11.421 years and the mean blood loss was 176.90+5.846 ml. In Group-A, mean heart rate at 0 minute, and 5 minutes was 76.54+1.786, and 76.65+1.296 while in Group-B was 75.50+2.568, and 73.88+1.886, respectively. In Group-A, mean SBP at 0, and 5 minutes was 108.17+3.191, and 107.17+2.234 while in Group-B was 106.25+3.795, and 103.56+1.821, respectively. Conclusion: Lidocaine hydrochloride 2% with epinephrine dose of 1:200,000 is more effective during endoscopic sinus surgery than epinephrine dose of 1:100,000 with Lidocaine hydrochloride 2%.