Search engine for discovering works of Art, research articles, and books related to Art and Culture
Javascript must be enabled to continue!
Molecular Dynamics Simulations of the FtsZ mutant G105S
View through CrossRef
Abstract
In our previous studies we simulated FtsZ monomer and dimer in different nucleotide binding states. In our simulations, we had used the
E.coli
FtsZ homology model including the FtsZ Intrinsically Disordered Region (IDR). Our simulations revealed that FtsZ dynamics involves a key stage in which GTP binds to monomeric FtsZ and opens its nucleotide binding site which in turn favours polymerization. During dimerization, the C-terminal of the top monomer rotates considerably towards the bottom monomer. Such a rotation of the C-terminal domain leads to capture of the nucleotide by its N-terminal domain. In this study we simulate the FtsZ G105S mutant to see if it may have ATPase activity which was reported in a previous study.
Title: Molecular Dynamics Simulations of the FtsZ mutant G105S
Description:
Abstract
In our previous studies we simulated FtsZ monomer and dimer in different nucleotide binding states.
In our simulations, we had used the
E.
coli
FtsZ homology model including the FtsZ Intrinsically Disordered Region (IDR).
Our simulations revealed that FtsZ dynamics involves a key stage in which GTP binds to monomeric FtsZ and opens its nucleotide binding site which in turn favours polymerization.
During dimerization, the C-terminal of the top monomer rotates considerably towards the bottom monomer.
Such a rotation of the C-terminal domain leads to capture of the nucleotide by its N-terminal domain.
In this study we simulate the FtsZ G105S mutant to see if it may have ATPase activity which was reported in a previous study.
Related Results
Examination of the interaction between FtsZ and MinC
N
in
E. coli
suggests how MinC disrupts Z rings
Examination of the interaction between FtsZ and MinC
N
in
E. coli
suggests how MinC disrupts Z rings
Summary
In
Escherichia coli
the Min system prevents Z ring assembly at cell poles by topologically re...
Determinants of FtsZ C-terminal linker-dependent regulation of cell wall metabolism in
Caulobacter crescentus
Determinants of FtsZ C-terminal linker-dependent regulation of cell wall metabolism in
Caulobacter crescentus
Abstract
Bacterial cell division requires assembly of a multi-protein machinery or “divisome” that remodels the cell envelope to cause constricti...
A conserved cell division protein directly regulates FtsZ dynamics in filamentous and unicellular actinobacteria
A conserved cell division protein directly regulates FtsZ dynamics in filamentous and unicellular actinobacteria
Bacterial cell division is driven by the polymerization of the GTPase FtsZ into a contractile structure, the so-called Z-ring. This essential process involves proteins that modulat...
A conserved cell division protein directly regulates FtsZ dynamics in filamentous and unicellular actinobacteria
A conserved cell division protein directly regulates FtsZ dynamics in filamentous and unicellular actinobacteria
AbstractBacterial cell division is driven by the polymerization of the GTPase FtsZ into a contractile structure, the so-called Z-ring. This essential process involves proteins that...
FtsZ treadmilling is essential for Z-ring condensation and septal constriction initiation in
Bacillus subtilis
cell division
FtsZ treadmilling is essential for Z-ring condensation and septal constriction initiation in
Bacillus subtilis
cell division
ABSTRACT
Despite the central role of division in bacterial physiology, how division proteins work together as a nanoscale machine to divide the c...
Molecular Dynamics Simulation of the
E.coli
FtsZ
Molecular Dynamics Simulation of the
E.coli
FtsZ
Abstract
Previous molecular dynamics studies of the FtsZ protein revealed that the protein has high intrinsic flexibility which the crystal struc...
Abstract 422: Novel approach to destabilization of oncogenic mutant p53 and therapeutic implications
Abstract 422: Novel approach to destabilization of oncogenic mutant p53 and therapeutic implications
Abstract
Introduction: Mutant p53 drives several hallmarks of cancer through a gain-of-function oncogenic program. The oncogenicity of mutant p53 includes sustained ...
Conformational flexibility Of A Highly Conserved Helix Controls Cryptic Pocket Formation In FtsZ
Conformational flexibility Of A Highly Conserved Helix Controls Cryptic Pocket Formation In FtsZ
Mycobacterium tuberculosis
is responsible for more than 1.6 million deaths per year. Overcoming failure from established therapies owing to multidrug resistance r...