Search engine for discovering works of Art, research articles, and books related to Art and Culture
Javascript must be enabled to continue!
Molecular Dynamics Simulations of the FtsZ mutant G105S
View through CrossRef
AbstractIn our previous studies we simulated FtsZ monomer and dimer in different nucleotide binding states. In our simulations, we had used theE.coliFtsZ homology model including the FtsZ Intrinsically Disordered Region (IDR). Our simulations revealed that FtsZ dynamics involves a key stage in which GTP binds to monomeric FtsZ and opens its nucleotide binding site which in turn favours polymerization. During dimerization, the C-terminal of the top monomer rotates considerably towards the bottom monomer. Such a rotation of the C-terminal domain leads to capture of the nucleotide by its N-terminal domain. In this study we simulate the FtsZ G105S mutant to see if it may have ATPase activity which was reported in a previous study.
Title: Molecular Dynamics Simulations of the FtsZ mutant G105S
Description:
AbstractIn our previous studies we simulated FtsZ monomer and dimer in different nucleotide binding states.
In our simulations, we had used theE.
coliFtsZ homology model including the FtsZ Intrinsically Disordered Region (IDR).
Our simulations revealed that FtsZ dynamics involves a key stage in which GTP binds to monomeric FtsZ and opens its nucleotide binding site which in turn favours polymerization.
During dimerization, the C-terminal of the top monomer rotates considerably towards the bottom monomer.
Such a rotation of the C-terminal domain leads to capture of the nucleotide by its N-terminal domain.
In this study we simulate the FtsZ G105S mutant to see if it may have ATPase activity which was reported in a previous study.
Related Results
Determinants of FtsZ C-terminal linker-dependent regulation of cell wall metabolism in
Caulobacter crescentus
Determinants of FtsZ C-terminal linker-dependent regulation of cell wall metabolism in
Caulobacter crescentus
Abstract
Bacterial cell division requires assembly of a multi-protein machinery or “divisome” that remodels the cell envelope to cause constricti...
A conserved cell division protein directly regulates FtsZ dynamics in filamentous and unicellular actinobacteria
A conserved cell division protein directly regulates FtsZ dynamics in filamentous and unicellular actinobacteria
Bacterial cell division is driven by the polymerization of the GTPase FtsZ into a contractile structure, the so-called Z-ring. This essential process involves proteins that modulat...
A conserved cell division protein directly regulates FtsZ dynamics in filamentous and unicellular actinobacteria
A conserved cell division protein directly regulates FtsZ dynamics in filamentous and unicellular actinobacteria
AbstractBacterial cell division is driven by the polymerization of the GTPase FtsZ into a contractile structure, the so-called Z-ring. This essential process involves proteins that...
Molecular Dynamics Simulation of the E.coli FtsZ
Molecular Dynamics Simulation of the E.coli FtsZ
AbstractPrevious molecular dynamics studies of the FtsZ protein revealed that the protein has high intrinsic flexibility which the crystal structures were unable to reveal. The ini...
Abstract 1706: Investigating the interaction between ETS family members and mutant p53
Abstract 1706: Investigating the interaction between ETS family members and mutant p53
Abstract
Cancer cases are on the rise globally requiring a deeper understanding of the disease and identification of novel therapeutic targets. Mutations in genes of...
Molecular Dynamics simulation of the E.coli FtsZ dimer
Molecular Dynamics simulation of the E.coli FtsZ dimer
AbstractFtsZ dimer was studied to gain insights into FtsZ protofilament formation. In a previous simulation study of the M.janaschii dimer it was found that the monomer-monomer con...
Cell cycle-dependent recruitment of FtsN to the divisome in
Escherichia coli
Cell cycle-dependent recruitment of FtsN to the divisome in
Escherichia coli
Abstract
Cell division in
Escherichia coli
starts with the formation of an FtsZ protofilament network in the ...
Bacterial Cell Division
Bacterial Cell Division
Abstract
Bacterial cell division or cytokinesis is the process in which a bacterial cell is split into two progeny cells, each wi...