Clinicopathological Profile of Molar Pregnancy at Al-Afia Hospital, Tripoli: A Retrospective Observational Study

Background and aims. Molar pregnancy is a rare form of gestational trophoblastic disease with variable incidence worldwide and limited epidemiological data in Libya. Most available Libyan studies are single-center reports, and comprehensive data from Tripoli are lacking. This study was conducted to characterize the demographic, clinical, and histopathological features of molar pregnancy among women clinically suspected of the disease at Al-Afia Private Hospital, Tripoli, between 2015 and 2020. Methods. This retrospective descriptive observational study reviewed medical and histopathological records of women evaluated for suspected molar pregnancy at Al-Afia Private Hospital over six years. Data collected included demographic characteristics, obstetric history, clinical presentation, blood group distribution, risk factors, pregnancy outcomes, and histopathological classification. Descriptive statistics were used to summarize categorical and continuous variables. Results. Out of 179 women clinically suspected of molar pregnancy, 38 cases were histopathologically confirmed, yielding a diagnostic confirmation rate of 21.2%. The mean age was 34.3 years, with the highest proportion occurring in women aged 30–39 years (44.7%). Most patients were multigravida (89.47%). Partial molar pregnancy was predominant (89.5%), while complete molar pregnancy accounted for 10.5% of cases. The most common blood group among confirmed cases was O positive (44.7%). A history of previous abortion was observed in 44.74% of patients. Pregnancy outcomes were predominantly abnormal, with missed abortion (36.84%) and incomplete abortion (18.42%) being the most frequent. Conclusion. Molar pregnancy at Al-Afia Hospital predominantly affected multigravid women in their third and fourth decades of life, with partial molar pregnancy being the most common histopathological type. The findings highlight the need for improved surveillance, standardized diagnostic approaches, and larger multicenter studies to better define the epidemiology of molar pregnancy in Libya.