THE PREVALENCE AND INFLUENCE OF DIABETES ON THE COURSE OF PULMONARY TUBERCULOSIS

Objective: Objective of the study is establish prevalence and influence of diabetes on the course of pulmonary tuberculosis. Design and method: Our study is based on an analysis of statistical data obtained from a retrospective study of 762 case histories and cases of MDR-TB in the register of tuberculosis patients in different regions of Ukraine and Grodno region of the Republic of Belarus for 2016-2020. Results: The retrospective analysis showed that in the patients included in the study, diabetes mellitus was detected in 28 cases (31.2%) simultaneously with the pulmonary tuberculosis; in 60 cases (68.8%) diabetes mellitus developed before tuberculosis and was the background for the manifestation of tuberculosis infection, with the average duration of the disease was 6.4 ± 1.2 years. Most patients had type 2 – 64 diabetes mellitus (72.7%). According to the severity of diabetes, patients were distributed as follows: moderate severity – 48 patients (54.5%), severe – 8 patients (9.1%) mild – 30 (36.4%). Depending on the form of diabetes compensation, the distribution was the following: compensated – 27 patients (30.7%), subcompensated – 49 patients (55.7%) and decompensated diabetes – 12 patients (13.6%). Most patients had type 2 – 64 diabetes mellitus (72.7%). According to the severity of diabetes, patients were distributed as follows: moderate severity – 48 patients (54.5%), severe – 8 patients (9.1%) mild – 30 (36.4%). According to the results of a clinical study of blood in both groups to the same extent recorded acceleration of ESR, anemia, leukocytosis, lymphopenia. On admission to the hospital, blood sugar averaged 10.6 ± 1.1 mmol / l in group 1 versus 3.7 ± 0.8 mmol / l. control groups. Conclusions: There is a clear tendency to increase the combined pathology and chemoresistance in the structure of the incidence of tuberculosis, the proportion of recurrences of tuberculosis in the presence of diabetes mellitus.