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Bioavailability of 99mTc-paclitaxel-glucuronide (99mTc-PAC-G)
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Abstract
An antitumor agent paclitaxel (PAC) has been proved to be efficient in the treatment of breast and ovarian cancer. Glucuronic acid-derived paclitaxel compound [paclitaxel-glucuronide (PAC-G)] was enzymatically synthesized using microsome preparate separated from rat livers. The biodistribution mechanism of PAC-G in healthy female Albino Wistar rats has been investigated. The expected structure is confirmed according to LC/MS results, and the possible attachment is to C2-hydroxyl group. PAC-G was labeled with 99mTc and the radiochemical yield of radiolabeled compound (99mTc-PAC-G) was 98.0±02.74 (n=9). The range of the breast/blood and breast/muscle ratios is approximately between 3 and 35 in 240ߙmin. All these experimental studies indicate that 99mTc-PAC-G may potentially be used in breast tissue as an imaging agent.
Walter de Gruyter GmbH
Title: Bioavailability of 99mTc-paclitaxel-glucuronide (99mTc-PAC-G)
Description:
Abstract
An antitumor agent paclitaxel (PAC) has been proved to be efficient in the treatment of breast and ovarian cancer.
Glucuronic acid-derived paclitaxel compound [paclitaxel-glucuronide (PAC-G)] was enzymatically synthesized using microsome preparate separated from rat livers.
The biodistribution mechanism of PAC-G in healthy female Albino Wistar rats has been investigated.
The expected structure is confirmed according to LC/MS results, and the possible attachment is to C2-hydroxyl group.
PAC-G was labeled with 99mTc and the radiochemical yield of radiolabeled compound (99mTc-PAC-G) was 98.
0±02.
74 (n=9).
The range of the breast/blood and breast/muscle ratios is approximately between 3 and 35 in 240ߙmin.
All these experimental studies indicate that 99mTc-PAC-G may potentially be used in breast tissue as an imaging agent.
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