Sleep aspects on video‐polysomnography in LRRK2 mutation carriers

AbstractBackgroundRapid eye movement sleep behavior disorder and sleepiness precede or accompany idiopathic Parkinson's disease (PD), but their presence in subjects with leucine‐rich repeat kinase 2 mutations is unknown.MethodsTen patients with leucine‐rich repeat kinase 2‐associated PD, four healthy leucine‐rich repeat kinase 2 mutation carriers, 20 patients with idiopathic PD, and 12 healthy controls underwent clinical assessments and a nighttime video‐polysomnography.ResultsNo sleep changes, no rapid eye movement sleep behavior disorder, or rapid eye movement sleep without atonia was found in the 14 subjects with leucine‐rich repeat kinase 2mutations compared with controls, whereas 41% of patients with idiopathic PD had rapid eye movement sleep behavior disorder. Eventually, 20% of patients with leucine‐rich repeat kinase 2–associated PD had abnormal periodic leg movements, a frequency similar to the idiopathic PD group frequency.ConclusionsThe sleep phenotype in leucine‐rich repeat kinase 2 mutations parallels that of idiopathic PD, except for absent rapid eye movement sleep behavior disorder here in the presymptomatic and symptomatic stages. © 2015 International Parkinson and Movement Disorder Society