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A Route to Benzo‐Annelated δ‐Sultams through Michael Cyclization
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AbstractA new approach to benzo‐annelated δ‐sultams containing an aryl–nitrogen bond is described. The method, which involves the intramolecular Michael cyclization of tert‐butyl ortho‐[N‐(methoxycarbonylmethyl)sulfonylamino]cinnamates, allows the synthesis of secondary sultams as well as their tertiary analogues and bridged tricyclic derivatives efficiently and diastereoselectively.
Title: A Route to Benzo‐Annelated δ‐Sultams through Michael Cyclization
Description:
AbstractA new approach to benzo‐annelated δ‐sultams containing an aryl–nitrogen bond is described.
The method, which involves the intramolecular Michael cyclization of tert‐butyl ortho‐[N‐(methoxycarbonylmethyl)sulfonylamino]cinnamates, allows the synthesis of secondary sultams as well as their tertiary analogues and bridged tricyclic derivatives efficiently and diastereoselectively.
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