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Sustainable Synthesis of Guanidine Derivatives and Computational Assessment of their Antidiabetic Efficacy
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Background:
Type 2 Diabetes Mellitus (T2DM) represents a significant and pressing
worldwide health concern, necessitating the quest for enhanced antidiabetic pharmaceuticals.
Guanidine derivatives, notably metformin and buformin, have emerged as pivotal therapeutic
agents for T2DM management.
Aims:
The present study introduces an efficient one-pot synthesis method for the production of
symmetrical guanidine compounds and subsequently, their evaluation as potential T2DM agents.
Methods:
This synthesis involves the reaction of isothiocyanates with secondary amines, employing
an environmentally friendly and recyclable reagent, tetrabutylphosphonium tribromide
(TBPTB). In order to understand the mechanics of ligand-protein interaction, ADME/Toxicity,
and drug-likeliness aspects, in silico studies were incorporated.
Results:
An efficient and easy method for synthesis of guanidine compounds has been devised.
Comprehensive assessment of the biological activity of the synthesized guanidine compounds,
specifically in the context of T2DM, has been rigorously conducted.
Conclusion:
Computational analyses have unveiled their substantial potential as promising antidiabetic
agents. Results highlight the relevance of these compounds in the ongoing pursuit of
novel therapeutic solutions for T2DM.
Title: Sustainable Synthesis of Guanidine Derivatives and Computational Assessment of their Antidiabetic Efficacy
Description:
Background:
Type 2 Diabetes Mellitus (T2DM) represents a significant and pressing
worldwide health concern, necessitating the quest for enhanced antidiabetic pharmaceuticals.
Guanidine derivatives, notably metformin and buformin, have emerged as pivotal therapeutic
agents for T2DM management.
Aims:
The present study introduces an efficient one-pot synthesis method for the production of
symmetrical guanidine compounds and subsequently, their evaluation as potential T2DM agents.
Methods:
This synthesis involves the reaction of isothiocyanates with secondary amines, employing
an environmentally friendly and recyclable reagent, tetrabutylphosphonium tribromide
(TBPTB).
In order to understand the mechanics of ligand-protein interaction, ADME/Toxicity,
and drug-likeliness aspects, in silico studies were incorporated.
Results:
An efficient and easy method for synthesis of guanidine compounds has been devised.
Comprehensive assessment of the biological activity of the synthesized guanidine compounds,
specifically in the context of T2DM, has been rigorously conducted.
Conclusion:
Computational analyses have unveiled their substantial potential as promising antidiabetic
agents.
Results highlight the relevance of these compounds in the ongoing pursuit of
novel therapeutic solutions for T2DM.
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