Efficient Synthesis of Quinone-Based Glycohybrids

Quinones are redox-active cyclic chemical compounds with two carbonyl groups in a six-membered ring structure, either contiguous or apart. Quinones are a diverse group of natural compounds that have gained attention for their pharmacological properties. This book chapter focuses on the design and synthesis of natural product-inspired quinone-based glycohybrids. Glycohybrids can have a broad variety of structural and functional properties, including protein-carbohydrate interactions that are essential for the biology of mammals and some disease states. These glycohybrids are designed based on the structures of bioactive aryl glycosides and quinones, aiming to enhance their binding affinity, enhanced bioavailability, high water solubility, low toxicity, and specificity toward cancer-related protein targets. This book chapter consistsof the literature from January 2017 to December 2023 and provides an overview of recent developments in the chemical synthesis of glycohybrids based on natural product scaffold of quinones.