Role of Platelet-Rich Plasma (PRP) in Wound Healing after Surgical Extraction Mandibular Third Molar

Objective: This Study looked into and discussed the role platelet-rich plasma plays in the healing of wounds after surgical extraction of the third tooth. It seeks to provide a general review of PRP, its composition, and its possible advantages over the Study group's control group, which had no PRP insertion, in terms of pain, healing, and swelling. Study Design: A prospective, randomized, comparative study Place and Duration of Study: This study was conducted at the Oral & Maxillofacial Surgery Department, Punjab Dental Hospital in Lahore from January 2022 to June 2023. Materials and Methods: The 38 patients who had surgical excision of their mandibular third molars were 19 males and 19 women. PRP was implanted but not in Group B, which included the patients (the control group), which was Group A, the Study group. Edoema, healing, and pain were assessed during the study at several time points (24 hours, three days, seven days, and 14 days). Results: Both groups' demographics were comparable, with an average age of 27.4 years (range, 18–40 years) and a similar distribution of genders. Comparing the PRP group to the control group, different elements of wound healing indicated a substantial improvement in the PRP group. Pain: The PRP group had significantly decreased pain after 24 hours (p 0.05), three days (p 0.01), and seven days (p 0.02) when compared to the control group. This implies that effective PRP use may minimise postoperative pain.2. edoema: Patients in the PRP group had significantly decreased edoema after three days (p0.01) and seven days (p0.01) when compared to the control group.3.Healing: A study of the overall healing of the wounds revealed that the PRP group healed more rapidly and more effectively than the control group. In comparison to the control group's 47% level of epithelialization seven days after surgery, 84% of the PRP group showed complete epithelialization. Additionally, after 14 days, 100% of the PRP group exhibited complete epithelialization compared to 68% of the control group. Conclusion: This comprehensive study provides evidence supporting the beneficial effects of PRP in the wound healing process after the surgical removal of the third molars on the mandible. By lowering postoperative pain and edoema, PRP usage significantly improved overall healing outcomes. When utilised as an adjuvant therapy in oral surgical procedures, PRP may enhance patient care and recovery.