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Many Families of Lids for TonB-dependent Transporters in Bacteroides
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Abstract
Most TonB-dependent transporters in
Bacteroides
belong to the SusC family and work with an outer-membrane lipoprotein from the SusD family that functions like a lid. But the best-studied strain,
B. thetaiotaomicron
VPI-5482, also contains 18 TonB-dependent transporters that are not from the SusC family. We identified six families of putative lids for these transporters. The putative lids are lipoproteins that are encoded next to TonB-dependent transporters, but they are not homologous to SusD. AlphaFold-Multimer predicts that the putative lids bind the outer faces of the corresponding TonB-dependent receptors. Genetic data suggests that members of four of these families are required for the activity of the corresponding TonB-dependent receptors. Overall, of the 18 TonB-dependent receptors that do not belong to the SusC family, we identified alternate lids for nine.
Title: Many Families of Lids for TonB-dependent Transporters in
Bacteroides
Description:
Abstract
Most TonB-dependent transporters in
Bacteroides
belong to the SusC family and work with an outer-membrane lipoprotein from the SusD family that functions like a lid.
But the best-studied strain,
B.
thetaiotaomicron
VPI-5482, also contains 18 TonB-dependent transporters that are not from the SusC family.
We identified six families of putative lids for these transporters.
The putative lids are lipoproteins that are encoded next to TonB-dependent transporters, but they are not homologous to SusD.
AlphaFold-Multimer predicts that the putative lids bind the outer faces of the corresponding TonB-dependent receptors.
Genetic data suggests that members of four of these families are required for the activity of the corresponding TonB-dependent receptors.
Overall, of the 18 TonB-dependent receptors that do not belong to the SusC family, we identified alternate lids for nine.
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