Search engine for discovering works of Art, research articles, and books related to Art and Culture
Javascript must be enabled to continue!
The Decrease in Spectrum Intensity of ESBL Spectra after Exposure to Clavulanic Acid in Nosocomial Urinary Tract Infected Escherichia coli Analysed by VITEK® MS
View through CrossRef
Abstract The present study aimed to investigate the influence of clavulanic acid on the spectrum intensity of Extended Spectrum β- Lactamase (ESBL) indicative spectra in the nosocomial urinary tract infected Escherichia coli. Two hundred nosocomial urinary tract infected E. coli isolates collected between 2017-2019 were recruited. Their antibiotic susceptibilities and ESBL productions were then determined. The effect of clavulanic acid contained in amoxicillin-clavulanic acid towards the change of spectra intensity after being exposed was also determined to identify their ESBL indicative spectra. Results revealed that these nosocomial isolates exhibited a low percent resistance after being tested to piperacillin-tazobactam, meropenem, doripenem, and gentamicin. VITEK® MS analysis demonstrated five E. coli species-specific spectra including 4363, 5097, 5381, 6255, and 9065 Dalton. After exposure to ceftazidime alone, and co-exposure to ceftazidime and amoxicillin-clavulanic acid, six ceftazidime-susceptible, and five ceftazidime-stress spectra, 5381, 6412, 7870, 8876,10139 and 10301 Dalton and 3578, 6226, 6316, 7274, and 8370 Dalton were significantly detected, respectively. Whereas two ceftazidime-resistant spectra, 4613 and 9715 Dalton, exhibited a significantly decreased intensity after determined in the high ESBL producing group after co-exposure to ceftazidime and clavulanic acid, respectively. In conclusion, an ESBL inhibitor or clavulanic acid could significantly decrease the spectrum intensity of two spectra 4613 and 9715 Dalton after being co-exposed to ceftazidime and clavulanic acid and these spectra were suspected as ESBL indicative spectra in the high ESBL producing nosocomial E. coli isolates. Keywords: Extended spectrum β- Lactamase indicative spectra, clavulanic acid exposure, nosocomial urinary tract infection, Escherichia coli, VITEK® MS
Title: The Decrease in Spectrum Intensity of ESBL Spectra after Exposure to Clavulanic Acid in Nosocomial Urinary Tract Infected Escherichia coli Analysed by VITEK® MS
Description:
Abstract The present study aimed to investigate the influence of clavulanic acid on the spectrum intensity of Extended Spectrum β- Lactamase (ESBL) indicative spectra in the nosocomial urinary tract infected Escherichia coli.
Two hundred nosocomial urinary tract infected E.
coli isolates collected between 2017-2019 were recruited.
Their antibiotic susceptibilities and ESBL productions were then determined.
The effect of clavulanic acid contained in amoxicillin-clavulanic acid towards the change of spectra intensity after being exposed was also determined to identify their ESBL indicative spectra.
Results revealed that these nosocomial isolates exhibited a low percent resistance after being tested to piperacillin-tazobactam, meropenem, doripenem, and gentamicin.
VITEK® MS analysis demonstrated five E.
coli species-specific spectra including 4363, 5097, 5381, 6255, and 9065 Dalton.
After exposure to ceftazidime alone, and co-exposure to ceftazidime and amoxicillin-clavulanic acid, six ceftazidime-susceptible, and five ceftazidime-stress spectra, 5381, 6412, 7870, 8876,10139 and 10301 Dalton and 3578, 6226, 6316, 7274, and 8370 Dalton were significantly detected, respectively.
Whereas two ceftazidime-resistant spectra, 4613 and 9715 Dalton, exhibited a significantly decreased intensity after determined in the high ESBL producing group after co-exposure to ceftazidime and clavulanic acid, respectively.
In conclusion, an ESBL inhibitor or clavulanic acid could significantly decrease the spectrum intensity of two spectra 4613 and 9715 Dalton after being co-exposed to ceftazidime and clavulanic acid and these spectra were suspected as ESBL indicative spectra in the high ESBL producing nosocomial E.
coli isolates.
Keywords: Extended spectrum β- Lactamase indicative spectra, clavulanic acid exposure, nosocomial urinary tract infection, Escherichia coli, VITEK® MS.
Related Results
96. Maternal Colonization, Perinatal Exposure, and Neonatal Acquisition of Resistant Enterobacterales
96. Maternal Colonization, Perinatal Exposure, and Neonatal Acquisition of Resistant Enterobacterales
Abstract
Background
Extended Spectrum Beta-Lactamase producing Enterobacterales (ESBL-E) are globally prevalent. Pregnant people...
Evolution of Antimicrobial Resistance in Community vs. Hospital-Acquired Infections
Evolution of Antimicrobial Resistance in Community vs. Hospital-Acquired Infections
Abstract
Introduction
Hospitals are high-risk environments for infections. Despite the global recognition of these pathogens, few studies compare microorganisms from community-acqu...
Phenotypic characterization and epidemiology of extended-spectrum β-lactamase-producing Enterobacteriaceae strains from urinary tract infections in Garoua, Cameroon
Phenotypic characterization and epidemiology of extended-spectrum β-lactamase-producing Enterobacteriaceae strains from urinary tract infections in Garoua, Cameroon
Background and objectivesThe emergence of extended-spectrum beta-lactamase-producing Enterobacteriaceae (ESBL-E) is causing increased morbidity and mortality around the world as a ...
Identification of Klebsiella pneumoniae strains harboring inactive extended-spectrum beta-lactamase antibiotic-resistance genes
Identification of Klebsiella pneumoniae strains harboring inactive extended-spectrum beta-lactamase antibiotic-resistance genes
Background
The extended-spectrum beta-lactamase (ESBL)-producing Klebsiella pneumoniae has increasingly become a major contributor to nosocomial infections and can exhi...
Extended-Spectrum-Beta-Lactamase (ESBL)-Producing Escherichia coli in Laying Hens: Slaughterhouse Prevalence and Antibiotic Resistance Patterns
Extended-Spectrum-Beta-Lactamase (ESBL)-Producing Escherichia coli in Laying Hens: Slaughterhouse Prevalence and Antibiotic Resistance Patterns
Background: Laying hens, which are widely utilized for consumption and export in various regions, experience prolonged antibiotic exposure due to their longer lifespan, increasing ...
Detection and Molecular Typing of Extended Spectrum Beta Lactamases (ESBLs) Producing Gram-Negative Bacteria from Wound Infections
Detection and Molecular Typing of Extended Spectrum Beta Lactamases (ESBLs) Producing Gram-Negative Bacteria from Wound Infections
ABSTRACT: Extended spectrum β-lactamases (ESBLs) producing bacteria, which are mainly Gram-negative, have emerged as a major threat in recent years as they are resistant to most an...
Clinicopathological and etiological characteristics for urinary tract infection in cervical cancer patients with radical surgery with double J stents
Clinicopathological and etiological characteristics for urinary tract infection in cervical cancer patients with radical surgery with double J stents
Abstract
Background
To investigate the clinicopathological and etiological characteristics for urinary tract infection in cervical cancer radical surgery with indwelling u...
Multidrug resistance, biofilm formation, and virulence genes of Escherichia coli from backyard poultry farms
Multidrug resistance, biofilm formation, and virulence genes of Escherichia coli from backyard poultry farms
Background and Aim: Backyard chicken flocks have traditionally been regarded as an essential food source in developed countries; however, they may act as reservoirs and spread vari...