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Spectrophotometric Determination of Some Catecholamine Drugs Using Metaperiodate
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Abstract
A rapid spectrophotometric procedure for the determination of Isoprenaline salts, levodopa, dopamine hydrochloride, and dobutamine hydrochloride, either In the drug substances or In pharmaceutical formulations, Is described. The method is based on the development of orange, red, or violet products with sodium metaperiodate in an aqueous alcoholic medium. The reaction is suggested to proceed via oxidative cyclizatlon of the catecholamine to form an amlnochrome. The wavelengths of maximum absorption range from 465 to 520 nm. The structure of the cyclization product was confirmed by ultraviolet, infrared, and nuclear magnetic resonance spectroscopy and microanalysis data.
Oxford University Press (OUP)
Title: Spectrophotometric Determination of Some Catecholamine Drugs Using Metaperiodate
Description:
Abstract
A rapid spectrophotometric procedure for the determination of Isoprenaline salts, levodopa, dopamine hydrochloride, and dobutamine hydrochloride, either In the drug substances or In pharmaceutical formulations, Is described.
The method is based on the development of orange, red, or violet products with sodium metaperiodate in an aqueous alcoholic medium.
The reaction is suggested to proceed via oxidative cyclizatlon of the catecholamine to form an amlnochrome.
The wavelengths of maximum absorption range from 465 to 520 nm.
The structure of the cyclization product was confirmed by ultraviolet, infrared, and nuclear magnetic resonance spectroscopy and microanalysis data.
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