ANXA2 Enhances the Malignancy of Gastric Cancer Cells by Remodeling Cytoskeleton

ANXA2 was reported as a multiple tumors relevant gene expressed excessively in many tumors, especially in cancers from the digestion system, and its aberrant expression enhances the malignant properties of cancer cells. We suppose that microstructure heterogeneity is important to maintain the malignancy of cancer cells, and ANXA2 excessive expression enhances the malignancy by remodeling the microstructures of cancer cells. To validate the proposal, we studied the effects of ANXA2 expression on the remodeling of motility-associated microstructures in SGC-7901 cells by a series of morphological display methods. The results showed that the cell motility microstructures, such as pseudopodia/filopodia and microvilli, were weaker and poorer in ANXA2-silenced SGC-7901 cells than in wild type cells, and the malignancy was significantly decreased in ANXA2 silenced SGC-7901 cells. These findings indicate that ANXA2 is necessary to maintain the changed cytoskeleton of cancer cells, especially the highly polymerized cytoskeleton protein, actin, and tubulin, which leads to the alteration of the cell microstructures that are closely correlated with cell motility. Our results indicate that ANXA2 plays an important role in enhancing the malignancy of gastric cancer cells by remodeling the cytoskeleton microstructures of polymerization. In this short article, we will try to shed light on this very important problem helping chronic pain patients to understand the nature of their pain and advising them how to deal with it.