The Expression and Significance of XB130 in Skin Basal Cell Carcinoma

Background: Skin basal cell carcinoma (BCC) is the most common skin cancer with an increasing incidence rate worldwide. XB130 is a novel adaptor protein for intracellular signal transduction and it participates in cell proliferation, cell survival, cell migration and cell apoptosis. Studies have demonstrated that XB130 is involved in cancer initiation and progression; however, its expression and role in BCC have not been investigated. Methods: Immunohistochemistry was carried out to detect the expression of XB130 at protein level in skin samples obtained from patients with skin basal cell carcinoma (n=40) and healthy donors (n=35). Results: In our study, we found that the staining of XB130 was mostly observed in cytoplasm. In normal skin tissues, XB130 was expressed almost in the whole layer of the epidermis. And the expression of XB130 in BCC was significantly down-regulated compared to normal skin. Conclusions: The study suggested that XB130 is involved in the pathogenesis of BCC and it may serve as a therapeutic target of BCC. Keywords: XB130; skin basal cell carcinoma;