e0281 Relationship between albuminuria and blood pressure level in patients with essential hypertension

Objective To investigate the relationship between albuminuria detection rate and blood pressure level or body weight index (BMI) in patients with essential hypertension in China's five regions. Method 5021 patients with clearly diagnosed essential hypertension but without diabetes were enrolled in our study. The participants came from five cities of China. Urinary albumin/creatinine ratio was measured in these patients for two times. The relationships between albuminuria and levels of blood pressure and BMI were analysed. Results 1. There wasn't any difference of the albuminuria incidence between patients less than 60-year-old and equal to or more than 60-year-old. The longer the hypertension exists, the higher the proportion of albuminuria. 2. The incidence of albuminuria associated with blood pressure levels significantly. The higher the blood pressure (BP) level, the more the urine protein excretion. The albuminuria detection rate in patients with normal blood pressure, high normal blood pressure, I, II or III stage hypertension were 26.3%, 27.3%, 28.7%, 31.5% and 40.3% respectively. 3. The incidence of albuminuria was different in patients with uncontrolled BP (BP>=140/90 mm Hg) compared with those with well controlled BP (<140/90 mm Hg) (27.1% vs 30.2%, p<0.05). 4. The incidence of albuminuria was in obese patients compared with those with normal body weight at equal blood pressure level, but the difference wasn't statistically significant. 5. Patients with albuminuria had more heart, cerebral or renal events than whom without proteinuria. Conclusion The detection rate of proteinuria in hypertensive patients without known diabetes was 28.8% in China, among them the incidence of microalbuminuria was 18.6%, and the incidence of clinical albuminuria was 10.2%. Uncontrolled BP was important risk factor of proteinuria.