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Meta-analyzing partial correlation coefficients using Fisher's z transformation

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The partial correlation coefficient (PCC) is used to quantify the linear relationship between two variables while taking into account/controlling for other variables. Researchers frequently synthesize PCCs in a meta-analysis, but two of the assumptions of the common equal-effect and random-effects meta-analysis model are by definition violated. First, the sampling variance of the PCC cannot assumed to be known, because the sampling variance is a function of the PCC. Second, the sampling distribution of each primary study's PCC is not normal since PCCs are bounded between -1 and 1. I advocate applying the Fisher's z transformation analogous to applying Fisher's z transformation for Pearson correlation coefficients, because the Fisher's z transformed PCC is independent of the sampling variance and its sampling distribution more closely follows a normal distribution. Reproducing a simulation study by Stanley and Doucouliagos and adding meta-analyses based on Fisher's z transformed PCCs shows that meta-analysis based on Fisher's z transformed PCCs had lower bias and root mean square error than meta-analyzing PCCs. Hence, meta-analyzing Fisher's z transformed PCCs is a viable alternative to meta-analyzing PCCs, and I recommend to accompany any meta-analysis based on PCCs with one using Fisher's z transformed PCCs to assess the robustness of the results.
Center for Open Science
Title: Meta-analyzing partial correlation coefficients using Fisher's z transformation
Description:
The partial correlation coefficient (PCC) is used to quantify the linear relationship between two variables while taking into account/controlling for other variables.
Researchers frequently synthesize PCCs in a meta-analysis, but two of the assumptions of the common equal-effect and random-effects meta-analysis model are by definition violated.
First, the sampling variance of the PCC cannot assumed to be known, because the sampling variance is a function of the PCC.
Second, the sampling distribution of each primary study's PCC is not normal since PCCs are bounded between -1 and 1.
I advocate applying the Fisher's z transformation analogous to applying Fisher's z transformation for Pearson correlation coefficients, because the Fisher's z transformed PCC is independent of the sampling variance and its sampling distribution more closely follows a normal distribution.
Reproducing a simulation study by Stanley and Doucouliagos and adding meta-analyses based on Fisher's z transformed PCCs shows that meta-analysis based on Fisher's z transformed PCCs had lower bias and root mean square error than meta-analyzing PCCs.
Hence, meta-analyzing Fisher's z transformed PCCs is a viable alternative to meta-analyzing PCCs, and I recommend to accompany any meta-analysis based on PCCs with one using Fisher's z transformed PCCs to assess the robustness of the results.

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