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Preparation and performance of 99Mo/99mTc chromatographic column generator based on zirconium molybdosilicate
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Abstract
Zirconium molybdosilicate (ZrMoSi) gel prepared using 99Mo radiotracer via peroxo route was used as a base material
for 99Mo/99mTc column generator. The 99mTc elution yield and 99Mo
breakthrough in the eluate were studied as a function of the pH-value of gel precipitation, gel drying temperature and
Zr:Mo:Si molar ratio. Precipitation pH-value of 2, drying temperature of 100 ℃ and
Zr:Mo:Si molar ratio of 0.5:0.5:1 were found to be the optimum conditions achieving 99mTc
elution yield of 82% and 99Mo breakthrough of 1.0E-3%. The gel prepared with the optimum conditions was
characterized by BET surface area and pore size analyzer, IR spectroscopy, thermal analysis (TGA and DTA), XRD, XRF and
FESEM. Technetium-99m eluted from the optimum ZrMoSi 99Mo/99mTc generator was found to have
a high radiochemical purity (98% as 99mTcO4
–
) and chemical purity meeting criteria of clinical grade.
Title: Preparation and performance of 99Mo/99mTc chromatographic column generator based on zirconium molybdosilicate
Description:
Abstract
Zirconium molybdosilicate (ZrMoSi) gel prepared using 99Mo radiotracer via peroxo route was used as a base material
for 99Mo/99mTc column generator.
The 99mTc elution yield and 99Mo
breakthrough in the eluate were studied as a function of the pH-value of gel precipitation, gel drying temperature and
Zr:Mo:Si molar ratio.
Precipitation pH-value of 2, drying temperature of 100 ℃ and
Zr:Mo:Si molar ratio of 0.
5:0.
5:1 were found to be the optimum conditions achieving 99mTc
elution yield of 82% and 99Mo breakthrough of 1.
0E-3%.
The gel prepared with the optimum conditions was
characterized by BET surface area and pore size analyzer, IR spectroscopy, thermal analysis (TGA and DTA), XRD, XRF and
FESEM.
Technetium-99m eluted from the optimum ZrMoSi 99Mo/99mTc generator was found to have
a high radiochemical purity (98% as 99mTcO4
–
) and chemical purity meeting criteria of clinical grade.
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