Lipid Mediators and Severity of Psoriasis

Abstract Psoriasis is one of the most common chronic inflammatory skin diseases resulting from a complex genetic background with environmental triggers. The bioactive Lipid mediators (12-hydroxyeicosatetraenoic acid (12-HETE) and 13-hydroxy octadecadienoic acid (13-HODE)) that generated involved in a variety of physiological and pathological processes. The study aims to assess the levels of bioactive lipid mediators (12- HETE and 13-HODE) in the serum and skin of psoriatic patients compared with healthy individuals and to study the association between the levels of bioactive lipid mediators in psoriatic patients with psoriasis severity measured by PASI score. Thirty-one patients with psoriasis were enrolled in the study, with 20 age and sex-matched apparently healthy subjects.The type of psoriasis and PASI score were assessed for psoriatic patients. Serum levels of 12-HETE, 13-HODE and other investigations were determined in psoriatic and healthy control groups, and the skin levels of 12-HETE and 13-HODE were also determined in lesional and non-lesional skin biopsies of psoriatic patients. There were statistically significant differences in the mean serum levels of 12-HETE and 13-HODE among the three psoriasis severity groups with (P =0.002, P =0.04), respectively. The serum levels of 12-HETE and 13-HODE were positively correlated with increasing psoriasis severity measured by PASI scorewith (r = 0.86, p =0.001), (r=0.87, p=0.001), respectively. In conclusion, The level of both lipid mediators (12-HETE and 13-HODE) had significantly increased in the serum of psoriatic patients with a significant positive correlation with the severity of psoriatic disease as assessed by the PASI scoring system.