Search engine for discovering works of Art, research articles, and books related to Art and Culture
Javascript must be enabled to continue!
Design, synthesis and antitumor activity evaluation of Benzimidazole derivatives with potent HDAC inhibitory activity
View through CrossRef
Abstract
This study aims to design and synthesize novel benzimidazole HDAC inhibitors to explore their potential applications in the treatment of cancer and other related diseases. By comparing the structures of our reported benzimidazole HDAC inhibitors, we designed a series of compounds accordingly. We then used experimentally verified their inhibitory activity against HDAC enzymes. The results showed that several of the newly synthesized compounds showed good HDAC inhibition and anti-proliferative activity. Therefore, we conclude that these novel HDAC inhibitors have potential as drug candidates for the treatment of cancer.
Title: Design, synthesis and antitumor activity evaluation of Benzimidazole derivatives with potent HDAC inhibitory activity
Description:
Abstract
This study aims to design and synthesize novel benzimidazole HDAC inhibitors to explore their potential applications in the treatment of cancer and other related diseases.
By comparing the structures of our reported benzimidazole HDAC inhibitors, we designed a series of compounds accordingly.
We then used experimentally verified their inhibitory activity against HDAC enzymes.
The results showed that several of the newly synthesized compounds showed good HDAC inhibition and anti-proliferative activity.
Therefore, we conclude that these novel HDAC inhibitors have potential as drug candidates for the treatment of cancer.
Related Results
SYNTHESIS AND POTENTIAL BIOLOGICAL ACTIVITY OF ANALOGUES OF THE DIBAZOL
SYNTHESIS AND POTENTIAL BIOLOGICAL ACTIVITY OF ANALOGUES OF THE DIBAZOL
The synthesis of benzimidazole derivatives, similar to dibazole, was carried out using two methods. According to the first, 1, 2-Phenylenediamine condensed with excess quantity of ...
Development of dual BET/HDAC inhibitors
Development of dual BET/HDAC inhibitors
Bezüglich der Arzneimittelforschung galt für sehr lange Zeit das Paradigma "ein Gen, ein Medikament, eine Krankheit". In jüngerer Zeit ändert sich dieses Paradigma jedoch auf Grund...
Pharmacological screening of synthetic piperidine derivatives
Pharmacological screening of synthetic piperidine derivatives
Piperidine derivatives are essential heterocyclic compounds that have beneficial roles in the medical and commercial sector. They can be isolated from plant material and can be che...
A Review on Synthesis and Characterisation of Benzimidazole
A Review on Synthesis and Characterisation of Benzimidazole
In the field of Medicinal Chemistry, the uses of heterocyclic compounds increased day by day, because in many biological materials, heterocyclic compound is a part of its structure...
Abstract 5120: NPRL2 gene therapy induces effective antitumor immunity in KRAS/STK11 mutant anti-PD1 resistant metastatic human NSCLC in a humanized mouse model
Abstract 5120: NPRL2 gene therapy induces effective antitumor immunity in KRAS/STK11 mutant anti-PD1 resistant metastatic human NSCLC in a humanized mouse model
Abstract
NPRL2/TUSC4 is a potent tumor suppressor gene whose expression is reduced in many cancers including NSCLC. Restoration of NPRL2 expression in cancer cells i...
Insights into the Antiparasitic Activity of Pyrazole-benzimidazole against Trypanosoma cruzi
Insights into the Antiparasitic Activity of Pyrazole-benzimidazole against Trypanosoma cruzi
Background:
Chagas disease (CD), a life-threatening disease caused by Trypanosoma
cruzi, remains a significant global public health concern. The limited efficacy
of the available d...
Design, Synthesis, Antitumor Activity Evaluation, and Molecular Dynamics Simulation of Some 2-aminopyrazine Derivatives
Design, Synthesis, Antitumor Activity Evaluation, and Molecular Dynamics Simulation of Some 2-aminopyrazine Derivatives
Objective:
Cancer poses a great threat to human health, and effective drugs to treat it
are always needed. Several compounds containing a 2-aminopyrazine framework have been
identi...