Differential effects of frailty on biventricular function and prognosis analysis in senile patients

Abstract Objective To investigate the differential effects of frailty on biventricular function in senile patients and analyse the prognosis of different combinations of clinical status. Methods and Results Patients aged ≥80 years with at least one basic disease causing heart failure were included and divided into three groups according to frailty score. Basic data, ultrasound data, and follow-up data were collected and analyses of differences between groups and survival were performed. The proportion of patients with right heart failure in the frailty group was significantly higher than that in the others. A total of 33 (15.1%) patients died within a year, 162 (74%) were readmitted within 1 year, and 84 (38.4%) were admitted for heart failure within 1 year. The frailty group with right heart failure had the highest rate of all cause and heart failure-related readmission. Frailty significantly increased the risk of 1-year all-cause mortality, all-cause readmission, and heart failure-related readmission. Right heart failure significantly increased the 1-year all-cause readmission and heart failure-related readmission rates. After adjusting for the interaction of factors, only frailty had a significant effect on the three prognostic events. Conclusions Right heart failure is more likely to be associated with frailty in senile patients. One-year all-cause mortality, all-cause readmission, and heart failure-related readmission rates were significantly increased in frail patients with right heart failure. Frailty was a significant predictor of all-cause death, all-cause readmission, and heart failure-related readmission.