Search engine for discovering works of Art, research articles, and books related to Art and Culture
Javascript must be enabled to continue!
Shikonin alleviates doxorubicin-induced cardiotoxicity via Mst1/Nrf2 pathway in mice
View through CrossRef
AbstractDoxorubicin (DOX) is a popular and potent anticancer drug, but its cardiotoxicity limits its clinical application. Shikonin has a wide range of biological functions, including antioxidant and anti-inflammatory effects. The aim of this study was to investigate the effects of shikonin on DOX-induced cardiac injury and to identify the underlying mechanisms. Mice receiving shikonin showed reduced cardiac injury response and enhanced cardiac function after DOX administration. Shikonin significantly attenuated DOX-induced oxidative damage, inflammation accumulation and cardiomyocyte apoptosis. Shikonin protects against DOX-induced cardiac injury by inhibiting Mammalian sterile 20-like kinase 1 (Mst1) and oxidative stress and activating the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway. In conclusion, shikonin alleviates DOX-induced cardiotoxicity by inhibiting Mst1 and activating Nrf2. Shikonin may be used to treat DOX-induced cardiac injury.
Springer Science and Business Media LLC
Title: Shikonin alleviates doxorubicin-induced cardiotoxicity via Mst1/Nrf2 pathway in mice
Description:
AbstractDoxorubicin (DOX) is a popular and potent anticancer drug, but its cardiotoxicity limits its clinical application.
Shikonin has a wide range of biological functions, including antioxidant and anti-inflammatory effects.
The aim of this study was to investigate the effects of shikonin on DOX-induced cardiac injury and to identify the underlying mechanisms.
Mice receiving shikonin showed reduced cardiac injury response and enhanced cardiac function after DOX administration.
Shikonin significantly attenuated DOX-induced oxidative damage, inflammation accumulation and cardiomyocyte apoptosis.
Shikonin protects against DOX-induced cardiac injury by inhibiting Mammalian sterile 20-like kinase 1 (Mst1) and oxidative stress and activating the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway.
In conclusion, shikonin alleviates DOX-induced cardiotoxicity by inhibiting Mst1 and activating Nrf2.
Shikonin may be used to treat DOX-induced cardiac injury.
Related Results
A Stress-Responsive Transcriptional Factor NRF2 Activates Hematopoietic Stem Cells
A Stress-Responsive Transcriptional Factor NRF2 Activates Hematopoietic Stem Cells
Abstract
KEAP1-NRF2 system is a major regulator of cellular redox balance and xenobiotic metabolism. NRF2 is an inducible transcription factor, and KEAP1 is its nega...
Shikonin supresses hepatocellular carcinoma by inhibiting JAG1/Notch1/uPA Signaling
Shikonin supresses hepatocellular carcinoma by inhibiting JAG1/Notch1/uPA Signaling
BackgroundShikonin, a bioactive naphthoquinone from Arnebiae Radix, exhibits hepatoprotective properties and anti-coagulation effects via inhibiting urokinase-type plasminogen acti...
GW24-e2975 Over-expression of calpastatin aggravates in vitro and in vivo cardiotoxicity induced by doxorubicin
GW24-e2975 Over-expression of calpastatin aggravates in vitro and in vivo cardiotoxicity induced by doxorubicin
Objectives
Doxorubicin often causes damage to the heart, which may present as cardiomyopathy. However, the mechanisms by which doxorubicin induces cardiotoxicity ...
P-008 Acetate ameliorates doxorubicin-induced testicular toxicity by modulating Nrf2/NFkB pathway and apoptotic signaling
P-008 Acetate ameliorates doxorubicin-induced testicular toxicity by modulating Nrf2/NFkB pathway and apoptotic signaling
Abstract
Study question
Will acetate treatment ameliorate doxorubicin-induced testicular toxicity when used concomitantly?
...
P–117 Bioinformatic analysis of NRF2 in the study of association of NRF2 variant and male infertility related to smoking status
P–117 Bioinformatic analysis of NRF2 in the study of association of NRF2 variant and male infertility related to smoking status
Abstract
Study question
Could Nrf2 polymorphism (–617C>A; rs6721961) and oxidative stress (OS)-induced changes of signatu...
P-117 Pre-selected for an award: Bioinformatic analysis of NRF2 in the study of association of NRF2 variant and male infertility related to smoking status
P-117 Pre-selected for an award: Bioinformatic analysis of NRF2 in the study of association of NRF2 variant and male infertility related to smoking status
Abstract
Study question
Could Nrf2 polymorphism (-617C>A; rs6721961) and oxidative stress (OS)-induced changes of signatu...
Oxidative stress sensor Keap1 recognizes HBx protein to activate the Nrf2/ARE signaling pathway, thereby inhibiting hepatitis B virus replication
Oxidative stress sensor Keap1 recognizes HBx protein to activate the Nrf2/ARE signaling pathway, thereby inhibiting hepatitis B virus replication
ABSTRACT
Hepatitis B virus (HBV) infection promotes reactive oxygen species production while paradoxically inducing the expression of antioxidant enzymes. HBV-induced dis...
Qingxiong Ointment and its Active Ingredient, Shikonin Treat Psoriasis
through HIF-1 Signaling Pathway
Qingxiong Ointment and its Active Ingredient, Shikonin Treat Psoriasis
through HIF-1 Signaling Pathway
Background:
Psoriasis is a common chronic inflammatory skin disorder. Qingxiong ointment (QX)
is a natural medicinal combination frequently employed in clinical treatment of psoria...