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The Identification of A Novel HIV-1 Second-Generation Recombinant form (CRF01_AE/CRF07_BC) Among Men Who Have Sex with Men in Jiangsu, China
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Background:
CRF01_AE and CRF07_BC are the two major HIV-1 virus strains circulating
in China. The proportion of dominant subtypes (CRF01_AE and CRF07_BC) among MSM
in Jiangsu province was over 80%. A large number of URFs have been found in China in recent
years.
Objective:
This study aimed to report on novel HIV-1 recombinants.
Method:
We constructed Phylogenetic trees using the maximum likelihood (ML) method with
1000 bootstrap replicates in IQ-TREE 1.6.8 software and determined recombination breakpoints using
SimPlot 3.5.1.
Results:
We identified a novel, second-generation HIV-1 recombinant (JS020202) between CRF01_
AE and CRF07_BC. The analysis of near full-length genome (NFLG) showed there were at
least 8 breakpoints in the virus, which differed from any previously identified CRF and URF
around the world.
Conclusion:
Novel diverse CRF01_AE/07_BC suggested the complexity trends of HIV-1 genetics.
The emergency situation of diverse recombinant strains should be monitored continuously.
Bentham Science Publishers Ltd.
Title: The Identification of A Novel HIV-1 Second-Generation Recombinant form (CRF01_AE/CRF07_BC) Among Men Who Have Sex with Men in Jiangsu, China
Description:
Background:
CRF01_AE and CRF07_BC are the two major HIV-1 virus strains circulating
in China.
The proportion of dominant subtypes (CRF01_AE and CRF07_BC) among MSM
in Jiangsu province was over 80%.
A large number of URFs have been found in China in recent
years.
Objective:
This study aimed to report on novel HIV-1 recombinants.
Method:
We constructed Phylogenetic trees using the maximum likelihood (ML) method with
1000 bootstrap replicates in IQ-TREE 1.
6.
8 software and determined recombination breakpoints using
SimPlot 3.
5.
1.
Results:
We identified a novel, second-generation HIV-1 recombinant (JS020202) between CRF01_
AE and CRF07_BC.
The analysis of near full-length genome (NFLG) showed there were at
least 8 breakpoints in the virus, which differed from any previously identified CRF and URF
around the world.
Conclusion:
Novel diverse CRF01_AE/07_BC suggested the complexity trends of HIV-1 genetics.
The emergency situation of diverse recombinant strains should be monitored continuously.
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