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A GIANT PROLACTINOMA: A CASE REPORT
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A 38-years-old woman presented to our hospital 2 years ago with 5-year history of reduced vision, chronic cephaleea
and secondary amenorrhea. Her baseline prolactin level was 46504 µIU/mL (reference range=127-637mUI/ml) with
secondary hypogonadism, and pituitary magnetic resonance imaging revealed a giant prolactinoma (4 × 2.2 × 2.6 cm3)
with suprasellar extension, optic chiasma and right cavernous sinus compression. She was initially treated with
cabergoline in order to reduce the prolactin level and tumoral mass, but after 6 months of medical treatment she proceed
to transsphenoidal tumor debulking surgery. Prolactin level dropped in the normal range only after the addition of
cabergoline treatment after surgery (1 mg/day 3 times/per week). However, the extensive tumour was not completely
resectable so she remained amenorrheic requiring hormone replacement therapy as well as thyroxine replacement due
to the development of TSH deficiency (free T4 6.03 pmol/L).
Title: A GIANT PROLACTINOMA: A CASE REPORT
Description:
A 38-years-old woman presented to our hospital 2 years ago with 5-year history of reduced vision, chronic cephaleea
and secondary amenorrhea.
Her baseline prolactin level was 46504 µIU/mL (reference range=127-637mUI/ml) with
secondary hypogonadism, and pituitary magnetic resonance imaging revealed a giant prolactinoma (4 × 2.
2 × 2.
6 cm3)
with suprasellar extension, optic chiasma and right cavernous sinus compression.
She was initially treated with
cabergoline in order to reduce the prolactin level and tumoral mass, but after 6 months of medical treatment she proceed
to transsphenoidal tumor debulking surgery.
Prolactin level dropped in the normal range only after the addition of
cabergoline treatment after surgery (1 mg/day 3 times/per week).
However, the extensive tumour was not completely
resectable so she remained amenorrheic requiring hormone replacement therapy as well as thyroxine replacement due
to the development of TSH deficiency (free T4 6.
03 pmol/L).
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