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Alkali-labile gangliosides
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Abstract
The structure and properties of a group of gangliosides modified by mild alkaline treatment are discussed. We will present the occurrence and the structure of gangliosides carrying the
N
-acetyneuraminic acid
O
-acetylated in position 9, the Neu5,9Ac
2
, and of gangliosides carrying a sialic acid that forms a lactone ring. Starting from biochemical data we will discuss the possible biochemical role played by these gangliosides in the processes of cell signaling and maintenance of brain functions.
Title: Alkali-labile gangliosides
Description:
Abstract
The structure and properties of a group of gangliosides modified by mild alkaline treatment are discussed.
We will present the occurrence and the structure of gangliosides carrying the
N
-acetyneuraminic acid
O
-acetylated in position 9, the Neu5,9Ac
2
, and of gangliosides carrying a sialic acid that forms a lactone ring.
Starting from biochemical data we will discuss the possible biochemical role played by these gangliosides in the processes of cell signaling and maintenance of brain functions.
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