AETIOLOGICAL ASPECTS OF THE DEVELOPMENT OF CHRONIC ENDOMETRITIS IN WOMEN WHO PLAN THEIR PREGNANCY

Introduction. In the structure of reproductive loss factors, the role of chronic endometritis is increasing that is obviously due to the persistence of microbial factors. However, the facts confirming the presence of intrauterine microflora and substantiating the appropriateness of antibacterial therapy of the above pathology are quite contradictory and prompt a detailed study of this issue. The purpose of this study is to investigate the spectrum of the microflora of the lower genital tract and the uterus in women who plan their pregnancy to clarify the role of ascending infection in the development of chronic endometritis. Subjects and methods. 87 women with histologically confirmed chronic endometritis (main group) and 13 women without this pathology (control group) were examined for the microflora spectrum of the lower genital tract and endometrial samples were studied by bacterioscopic, bacteriological methods and polymerase chain reaction. Results. Pathological microflora in the cervical canal and vagina in women with chronic endometritis was detected in 75% that is 2.85 times higher than the frequency of the infection detection in women without this pathology (30.7%). The microflora was mainly represented in the form of polymicrobial associations. The spectrum of microorganisms in the cervical canal and vagina mostly coincided with those in the endometrial samples. Most often, Ureaplama spp. (63.2%), chlamydia (31.6%), mycoplasma (26.3%) were detected in the endometrium. Conclusion. The study has emphasized the key role of ascending infection in the development of chronic endometritis and the need for sanitation of the lower genital tract during its comprehensive treatment.