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Pulmonary Embolism in Vaccine-Induced Thrombotic Thrombocytopaenia: Under-Reported?

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Vaccine-induced thrombotic thrombocytopenia (VITT) is a rare, newly described syndrome characterised by thrombocytopenia and thrombosis 5–24 days after administration of an adenoviral vector-based COVID-19 vaccine. It resembles heparin-induced thrombocytopenia and, therefore, diagnostics and treatment are similar. Early recognition is essential to avoid potentially fatal outcomes. This article describes a case of VITT with symptomatic cerebral venous-sinus thrombosis and splanchnic vein thrombosis, as well as asymptomatic pulmonary embolism in a 49-year-old male. The authors discuss VITT, focusing on the possibility of pulmonary embolism being under-reported, diagnostic criteria, differential diagnosis, and treatment.

European Medical Group

Veerle Leenaerts Michael Staes Jos Callens Pieter Monballyu

EMJ Respiratory

Title: Pulmonary Embolism in Vaccine-Induced Thrombotic Thrombocytopaenia: Under-Reported?

Description:

Vaccine-induced thrombotic thrombocytopenia (VITT) is a rare, newly described syndrome characterised by thrombocytopenia and thrombosis 5–24 days after administration of an adenoviral vector-based COVID-19 vaccine.

It resembles heparin-induced thrombocytopenia and, therefore, diagnostics and treatment are similar.

Early recognition is essential to avoid potentially fatal outcomes.

This article describes a case of VITT with symptomatic cerebral venous-sinus thrombosis and splanchnic vein thrombosis, as well as asymptomatic pulmonary embolism in a 49-year-old male.

The authors discuss VITT, focusing on the possibility of pulmonary embolism being under-reported, diagnostic criteria, differential diagnosis, and treatment.

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