Congenital Diaphragmatic Hernia in Neonates

Background: There are no standard criteria to select patients for thoracoscopic repair of congenital diaphragmatic hernia (CDH). The objective of this study was to compare open laparotomy versus thoracoscopic repair of CDH in neonates. Patients and Methods: This retrospective study included 41 patients who had repair of CDH from 2011 to 2019. Patients were divided into two groups according to the surgical approach; open laparotomy ( n = 30) and thoracoscopic repair ( n = 11). Study endpoints were duration of post-operative mechanical ventilation, hospital stay and the return to full enteral feeding. Results: Patients who had thoracoscopic repair were significantly younger (3 [25 th - 75 th percentiles: 3-3] vs. 4 [3–5] days; P = 0.004). Other pre-operative variables were comparable between both groups. The duration of surgery was significantly longer in the thoracoscopic repair (174 [153–186] vs. 91 (84–99) min; P < 0.001). The use of pre-operative nitrous oxide inhalation was associated with prolonged ventilation ( P = 0.004), while the thoracoscopic repair was associated with shorter mechanical ventilation ( P = 0.006). Hospital stay is lower in the thoracoscopic approach but did not reach a significant value ( P = 0.059). The use of pre-operative nitrous oxide was associated with a prolonged hospital stay ( P = 0.002). Younger age (HR: 1.33, P = 0.014) and open approach (HR: 3.56, P = 0.004) were significantly associated with delayed feeding. Conclusions: The thoracoscopic approach is safe and effective for repairing the CDH. It is associated with shorter mechanical ventilation and rapid return to enteral feeding. Proper patient selection is essential to achieve good outcomes.