Corneal stress-strain index in myopic Indian population

Abstract AIM: The purpose is to study the corneal stress-strain index (SSI) in myopic refractive error among Indian subjects. METHODS: A retrospective study where young myopic subjects aged between 11 and 35 years who had undergone corneal biomechanics assessment using Corvis ST between January 2017 and December 2021 were enrolled. Subjects with central corneal thickness (CCT) <500 m, intraocular pressure (IOP) >21 mmHg, history of any systemic and ocular disease or any previous ocular surgery, high astigmatism, corneal disease such as keratoconus were excluded. Subjects with missing data or having poor quality scan were excluded. Corneal biomechanical properties and corneal SSI were assessed using Corvis ST. For statistical purposes, eyes were divided into four different groups and were analyzed using one-way ANOVA. RESULTS: Nine hundred and sixty-six myopic eyes with mean ± standard deviation age, IOP, and CCT of 26.89 ± 4.92 years, 16.94 ± 2.00 mmHg, and 540.18 ± 25.23 microns, respectively, were included. There were 311, 388, 172, and 95 eyes that were low, moderate, severe, and extreme myopic. Deformation amplitude ratio at 1 mm and 2 mm were similar across different myopic groups. A significant increase in max inverse radius, ambrosia relational thickness, biomechanically corrected IOP, integrated radius was noted with an increase in myopic refractive error. Corvis biomechanical index, corneal SSI was found to be decreased significantly with an increase in myopic refractive error. We noted a significant positive association between myopic refractive error and SSI (P < 0.001). CONCLUSION: Corneal SSI was found to be reduced in extreme myopic eyes.