A clinical study on the combined effectiveness of Pathyadi Churna and Kshara Basti in Amavata (Rheumatoid Arthritis)

Background & Objectives: Amavata (Rheumatoid Arthritis-RA) is a disease caused due to deranged Agni leading to Ama formation. The Lakshanas are very similar to Rheumatoid Arthritis (RA), an autoimmune disorder which causes chronic inflammation and symmetric, peripheral polyarthritis. Pathyadi Churna and Kshara Basti are mentioned in the classics for the treatment of Amavata. Methods: Among 33 registered patients, 30 of them completed the course of treatment. They were administered with Pathyadi Churna 1 Karsha (12g) thrice daily before food with Ushnodaka as Anupana (adjuvant) for a period of 15 days along with Kshara Basti in a modified Yoga Basti format for the first 5 days.  Friedman's test with Wilcoxon sign rank test as post hoc was used to analyze the significance of change in Ordinal data and Repeated measure ANOVA after applying Bonferroni correction and Paired t test as post hoc was used to analyze the significance of change in Scale data. Results: There was statistically significant improvement in the primary and secondary outcome measures of Amavata. Interpretation and Conclusion: Pathyadi Churna and Kshara Basti are effective in the management of Amavata.