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Molecular Basis of Macrolide, Triamilide, and Lincosamide Resistance in Pasteurella multocida from Bovine Respiratory Disease
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ABSTRACT
The mechanism of macrolide-triamilide resistance in
Pasteurella multocida
has been unknown. During whole-genome sequencing of a multiresistant bovine
P. multocida
isolate, three new resistance genes, the rRNA methylase gene
erm
(42), the macrolide transporter gene
msr
(E), and the macrolide phosphotransferase gene
mph
(E), were detected. The three genes were PCR amplified, cloned into suitable plasmid vectors, and shown to confer either macrolide-lincosamide resistance [
erm
(42)] or macrolide-triamilide resistance [
msr
(E)-
mph
(E)] in macrolide-susceptible
Escherichia coli
and
P. multocida
hosts.
Title: Molecular Basis of Macrolide, Triamilide, and Lincosamide Resistance in Pasteurella multocida from Bovine Respiratory Disease
Description:
ABSTRACT
The mechanism of macrolide-triamilide resistance in
Pasteurella multocida
has been unknown.
During whole-genome sequencing of a multiresistant bovine
P.
multocida
isolate, three new resistance genes, the rRNA methylase gene
erm
(42), the macrolide transporter gene
msr
(E), and the macrolide phosphotransferase gene
mph
(E), were detected.
The three genes were PCR amplified, cloned into suitable plasmid vectors, and shown to confer either macrolide-lincosamide resistance [
erm
(42)] or macrolide-triamilide resistance [
msr
(E)-
mph
(E)] in macrolide-susceptible
Escherichia coli
and
P.
multocida
hosts.
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