106 Trends, Predictors, and Outcomes of Septic Shock in Patients With Pancreatitis

INTRODUCTION: Patients with pancreatitis are at an increased risk of developing infections. The goal of our study was to determine the association of septic shock on in-hospital outcomes among patients with pancreatitis as well as the risk factors. METHODS: A retrospective study using the National Inpatient Sample database (2003–2016) was used to identify acute pancreatitis patients with and without septic shock. A linear regression analysis was used to assess the impact of septic shock on patients hospitalized with acute pancreatitis. A univariate logistic regression was used to determine comorbid conditions and predictors for septic shock in this cohort. RESULTS: We identified 7158894 pancreatitis patients between 2003–2016. Patients hospitalized for pancreatitis with and without septic shock had similar baseline characteristics. The incidence of septic shock was highest among patients aged >65 ( P < 0.001). Septic shock was associated with significantly higher mortality among those with pancreatitis (34.4% vs 1.5%, P < 0.001). Septic shock was associated with 3 times longer hospitalization (12 days versus 4 days, P < 0.001), higher median hospital cost ($117907 vs $21563, P < 0.001), respiratory failure (60.7% vs 3.6%, P < 0.001), and renal failure (61.6% vs 9.2%, P < 0.001). Septic shock was more likely in patients with comorbidities including diabetes, COPD, and CAD. CONCLUSION: Our study found that septic shock in acute pancreatitis patients is associated with increase in mortality, length of stay, and health care utilization. More investigation is needed to further understand how to best mitigate some of these predictors for mortality.