FIGURE 2 from A Systems Biology Approach to Understand the Racial Disparities in Colorectal Cancer

<p>Kaplan–Meier curves of overall survival for the most significant gene of each colorectal cancer STN for the Black/AA and White cohort. <b>A,</b> WNT7B for WNT STN for the Black/AA cohort. <b>B,</b> CSNK1A1 for WNT STN for the White cohort. <b>C,</b> TP73 for TP53 STN for the Black/AA cohort. <b>D,</b> IGFBP3 for TP53 STN for the White cohort. <b>E,</b> EID2 for TGFβ STN for the Black/AA cohort. <b>F,</b> RAC1 for TGFβ STN for the White cohort. <b>G,</b> NTF4 for PI3K-Akt STN for the Black/AA cohort. <b>H,</b> BRAC1 for PI3K-Akt STN for the White cohort. <b>I,</b> EIF4E for mTOR STN for the Black/AA cohort. <b>J,</b> RRAGB for mTOR STN for the White cohort. <b>K,</b> CACNA2D4 for MAPK STN for the Black/AA cohort. <b>L,</b> TGFB2 for MAPK and Cell Cycle STN for the White cohort. <b>M,</b> YWHAQ for Cell Cycle STN for the Black/AA cohort. <b>N,</b> CASP6 for Apoptosis STN for the Black/AA cohort. <b>O,</b> IKBKG for Apoptosis STN for the White cohort. <b>P,</b> NOTCH3 for Notch STN for the Black/AA cohort. <b>Q,</b> DTX1 for Notch STN for the White cohort. The patients were stratified into two groups according to the expression level of the indicated gene. The optimal cutoff was determined using Kaplan–Meier scanning (see Materials and Methods). The groups are represented as high (orange line), and low (blue line), where <i>n</i> indicates the total number of patients in each group. Statistical significance was tested using a log-rank test. HR = hazard ratio. CI_95% = 95% confidence interval. <i>P</i>-val = <i>P</i>-value.</p>