EFFECT OF FAMOTIDINE ON HYPOGLYCAEMIC ACTIVITY OF GLIBENCLAMIDE

Objective: To study the effect of famotidine (H2 receptor antagonist) in combination with Glibenclamide on the blood sugar level in rabbits. Methods: Six albino rabbits were taken for the study. Glibenclamide was administrated to each rabbit as a single drug therapy on day 1, while was co-administrated with Famotidine to each rabbit as a combinational drug therapy on day 7. Famotidine was administrated to each rabbit from day 2 to day 6 as a single drug therapy. Blood sugar levels were estimated on day 1 and on day 7 at 0, 1, 2, 4, and 6 h. Results: The mean blood sugar level readings at 0, 1, 2, 4 and 6 h on day 1 were 91.1, 79.7, 70.6, 61.8 and 66.5 mg% and on day 7 were 91.1, 78.5, 69.6, 60.6 and 64.9 mg%, respectively. When blood sugar level on day 1 and 7 were compared, there was. no significant change in any of the readings after co-administration of Glibenclamide and Famotidine. Conclusion: Famotidine did not produce any significant reduction in Blood sugar level when it was co-administered with glibenclamide