COMPARISON OF HELICOBACTER PYLORI?INFECTION AND PEPTIC ULCER DISEASE IN CIRRHOTIC AND NON CIRRHOTIC PATIENTS

Objective: This study aims to evaluate the relationship of helicobacter pylori infection and peptic ulcer disease in cirrhotic patient in order to clarify its role in ulcer pathogenesis.  Methods: Among 160 participants, two groups were formed (cirrhotic and non-cirrhotic) based on chemical, biochemical and radiologic findings. Helicobacter pylori serology was done to diagnose h-pylori positive patient. Peptic ulcer bleed was classified according to forrest classification. Upper gastrointestinal endoscopies were performed followed by colonoscopy, incase if there was ulcer in the duodenum to confirm that the bleed was from that specific ulcer. Endoscopy was performed by 4 interventional Gastroenterologist. The data recorded for each patient was demographic variables including age, gender, H-pylori serology, endoscopic findings and routine blood tests.   Results: In 160 participants the mean age was 50±3 year with minimum and maximum ages being 40 and 60 respectively. The study distribution of males to females was equal i.e. 50%. Similarly 23.1 % patients were below 50 years while 76.9% were above 50 years. H-pylori serology was positive in 57.1% while 42.9% were negative. The results reveal that there is no statistically significant association between liver cirrhosis (p-value 0.05) and h-pylori infection. However, female gender was significantly associated with h-pylori infection (p–value <0.001). There was no association between age and h- pylori infection (p- value 0.50).  Conclusions: Our study concludes that there is no strong association between liver cirrhosis and h-pylori infection. However, female patients have higher frequency of h-pylori infection than male. The endoscopic finding also reveals that cirrhotic patients had severed PUD endoscopic features as compared to non-cirrhotic patients.