Supplementary figure and legend from Spatiotemporal Regulation of Tumor Angiogenesis by Circulating Chromogranin A Cleavage and Neuropilin-1 Engagement

<p>Sup Fig 1: Characterization of mAb 9D1 and its effects on tumor growth and NRP1/CgA1-373 interaction; Sup Fig 2: Effect of aprotinin treatment on tumor growth and CgA cleavage; Sup Fig 3: Anti-PGPQLR monoclonal and polyclonal antibodies inhibit tumor growth in various murine models; Sup Fig 4: Effect of anti-PQLR IgGs (highly specific for CgA1-373) and anti-QALRRG (C-terminal region of CgA1-439) on tumor growth; Sup Fig 5: Effect of anti-PGPQLR on WEHI-164 fibrosarcoma tumor vasculature; Sup Fig 6: Effect of CgA1-373 and FGF2 on HUVEC proliferation; Sup Fig 7: NRP1, but not NRP2, binds CgA1-373; the binding is blocked by anti-PGPQLR or anti-PQLR antibodies; Sup Fig 8: Effects of CgA1-373 and VEGF on VEGF-R2 phosphorylation at tyrosine (Y) residues 951, 996 or 1175 in HUVEC.</p>