Caffeine Associated with Exercise Actions on Glycemic Metabolism and Insulin Resistance in Diabetic Animals

Objective: evaluate glycemic metabolism and its relationship with insulin resistance in diabetic animals after caffeine consumption associated with exercise.Material and Methods: 48 animals, of 60 days, divided in four groups: Control, Diabetic, Control+Exercise, Diabetes+Exercise, Caffeine, Diabetes+Caffeine, Exercise+Caffeine and Diabetes+Caffeine+Exercise. Diabetes model was induced by intraperitoneal administration of 120 mg/kg of alloxan. On the test day, 6 mg/kg of caffeine were administrated 30 minutes before exercise and the animals performed a 60 minutes’ session of predominantly aerobic exercise, using an overload of 6% of their body’s weight. With 90 days old, the animals were submitted to an oral glucose tolerance test (OGTT) to verify their glycemic curve. During thirty days of aerobic exercise and/or caffeine treatment, the animals had their glycemia evaluated. At the end of the period, the OGTT was re-evaluated. So, the animals were sacrificed for biochemical analysis (glucose, muscle glycogen and hepatic) and hormonal (insulin). The animals were trained during 30 days by swimming tank, with 4% of extra weight a 40-minute session, daily.Results: Caffeine treatment increased plasma insulin concentration compared to healthy controls (95%, p