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Comparative Study of Neuropharmacological Activity of <i>Majoon-E-Flasfa</i> and its Redesigned Dosage Forms in Experimental Animal Models
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<i>Background</i>: The age associated cognitive disorders like amnesia and Alzheimers disease significantly affect the productivity of an individual and the quality of life. Due to the side effects of nootropic agents, phytomedicine is considered to be an effective alternative with very less or no side effects. Researchers continue to work on sustaining the cognition by implementing the synergistic effect of nutrition and herbal medicine on an individual to help in restoring a healthy and positive attitude towards life.<br><i>Objective</i>: The present study aims at comparative evaluation of neuropharmacological effect<br>of Unani classical sugar-based dosage form MF and its redesigned dosage forms i.e. tablet<br>made from powder (TP), tablet made from aqueous extract (TAE) and tablet made from<br>hydroalcoholic extract (THAE) in rats.<br><i>Materials & methods</i>: The test group animals were administered with 1166.67mg/kg, p.o., of MF, TP in the dose of 303.33 mg/kg, p.o., TAE in the dose of 291.35 mg/kg, p.o., THAE in<br>the dose of 303.27 mg/kg, p.o., and the control group animals with equal volume of distilled<br>water orally. Neuropharmacological actions which include gross behavior, Narcosis<br>potentiation, spontaneous motor activity, neuromuscular coordination, analgesic effect,<br>anticonvulsant activity, conditioned avoidance response, and learning behavior and Memory,<br>working memory and spatial working memory were studied.<br><i>Results</i>: Treatment with conventional and redesigned dosage forms indicated a possible<br>antidepressant and analgesic effect, psychomotor performances, anticonvulsant activity,<br>spontaneous motor activity, anxiolytic and behavior and memory (maze models) with no<br>response on muscular coordination.<br><i>Conclusions</i>: The study revealed that the redesigned form i.e. THAE exerted more significant results as compared to other dosage forms.<br>
Title: Comparative Study of Neuropharmacological Activity of
<i>Majoon-E-Flasfa</i> and its Redesigned Dosage Forms in Experimental Animal Models
Description:
<i>Background</i>: The age associated cognitive disorders like amnesia and Alzheimers disease significantly affect the productivity of an individual and the quality of life.
Due to the side effects of nootropic agents, phytomedicine is considered to be an effective alternative with very less or no side effects.
Researchers continue to work on sustaining the cognition by implementing the synergistic effect of nutrition and herbal medicine on an individual to help in restoring a healthy and positive attitude towards life.
<br><i>Objective</i>: The present study aims at comparative evaluation of neuropharmacological effect<br>of Unani classical sugar-based dosage form MF and its redesigned dosage forms i.
e.
tablet<br>made from powder (TP), tablet made from aqueous extract (TAE) and tablet made from<br>hydroalcoholic extract (THAE) in rats.
<br><i>Materials & methods</i>: The test group animals were administered with 1166.
67mg/kg, p.
o.
, of MF, TP in the dose of 303.
33 mg/kg, p.
o.
, TAE in the dose of 291.
35 mg/kg, p.
o.
, THAE in<br>the dose of 303.
27 mg/kg, p.
o.
, and the control group animals with equal volume of distilled<br>water orally.
Neuropharmacological actions which include gross behavior, Narcosis<br>potentiation, spontaneous motor activity, neuromuscular coordination, analgesic effect,<br>anticonvulsant activity, conditioned avoidance response, and learning behavior and Memory,<br>working memory and spatial working memory were studied.
<br><i>Results</i>: Treatment with conventional and redesigned dosage forms indicated a possible<br>antidepressant and analgesic effect, psychomotor performances, anticonvulsant activity,<br>spontaneous motor activity, anxiolytic and behavior and memory (maze models) with no<br>response on muscular coordination.
<br><i>Conclusions</i>: The study revealed that the redesigned form i.
e.
THAE exerted more significant results as compared to other dosage forms.
<br>.
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