Pharmaceutically Privileged Bioactive Pyridine Derivatives as Anticancer Agents: Synthetic Developments and Biological Applications

Pyridine is an N-containing heterocyclic compound that exists naturally and accounts for a wide range of biological activities. The medicinal and pharmacological features of the substituted pyridine derivatives make them as an important scaffold for consideration in synthetic organic chemistry. Numerous pyridine derivatives have been established to inhibit kinases, androgen receptors, tubulin polymerization, topoisomerase enzyme, human carbonic anhydrase, and several additional targets against cancer. The privileged scaffold pyridine has consistently functioned in a wide range of FDA-approved pharmaceutical candidates. Researchers are currently focusing on exploring the new synthetic method for the development of novel pyridine molecules with additional moieties for cancer treatment. This section discusses the synthesis of bioactive pyridine derivatives, and their biological expansions as anticancer agents.