EVALUATION OF THE SEDATIVE EFFECT OF PROPOFOL IN COMBINATION WITH FENTANYL IN COLONOSCOPY

Background: Colonoscopy is one of the most common procedures. Sedation and analgesia decrease anxiety and discomfort and minimize risks. Therefore, patients prefer to be sedated in examination. Until now, there is no known drug that is ideal for sedation during colonoscopy. Recently, Propofol is an intravenous hypnotic with rapid onset and short duration of action, thus, propofol has assumed a prominent position.The combination propofol with opioids are used to relieve the patient’s pain and discomfort. Objectives: Comparison of propofol alone in combination with different doses of fentanyl to find the most effective dose for sedation in colonoscopy. Methods: In a prospective, randomized clinical study, 120 patients who underwent colonoscopy at the Hue University of Medicine and Pharmacy Hospital. Patients in this study were divided into three groups: Group I received intravenous fentanyl (0.5 mcg/kg) 2-3 min followed by propofol (1.5 mg/kg) IV; Group II received fentanyl (1.0 mcg/kg) 2-3 min followed by propofol (1.5 mg/kg) IV; Group III received intravenous anesthesia propofol (1.5 mg/kg). If the patient is awake during endoscopy, bolus propofol 0.5 mg/kg. The study variables included: pulse, blood pressure, oxygen saturation, quality of sedation, total dose of propofol used, number of awakenings, time to resuscitation, patient and endoscopist satisfaction, side effects of sedation such as slow pulse, low blood pressure, respiratory failure, nausea,.... Results: Patients in Group II had either lower incidence of reaction (motor or verbal) to the colonoscopyintroduction or lower propofol consumption but awaking-time was longer. The time from stop propofol until the patient was awake was longer in group 2 than in group 1 and group 3. Group 2 reached the desired level of sedation faster than group 1 and group 3. Other results was not different between three groups. Conclusion: The combination of fentanyl (1.0 mcg/kg) and propofol (1.5 mg/kg) for colonoscopy sedation reduces propofol consumption and provides greater result. Key words: Colonoscopy, fentanyl, propofol.