Hepcidin level and Other Biochemical Parameters in Iraqi Acromegaly Diabetic Patients.

Acromegaly is a rare disease resulting from excessive growth hormone and insulin-like growth factor -1 associated with long-term comorbidities. This study aimed to find the effect of hepcidin and other biochemical parameters in acromegaly diabetic patients. This study was done at the National Diabetes Center/Mustansiriyah University between October 2021 and the end of April 2022. Nighty participated in this study (50) acromegaly diabetic patients and (40) healthy control compared patients. An especially significant increase in fasting blood sugar, HbA1c, total cholesterol, Triglycerides, Growth hormone, and IGF-1 in acromegaly Diabetic patients when compared with the control group. While there was a highly significant decrease in high-density lipoprotein among acromegaly Diabetic patients compared with the control group, there was a highly significant decrease in Hepcidin, Iron, and Ferritin in acromegaly Diabetic patients compared to control. It can be concluded that low levels of hepcidin in diabetic acromegaly patients, compared with healthy subjects, have a significant role in iron and ferritin levels in the human body. Therefore, their decrease affects diabetes metabolism and heart metabolism. Therefore, moderate levels of hepcidin, iron, and ferritin must be maintained, which protects against heart disease. Keywords: Hepcidin, Iron, Ferritin, Lipid profile, acromegaly.