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Study on some clinical features, histopathology and mutations in IDH, P53 genes, mgmt methylation in patients with high-grade glioma
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Objectives: To describe some genes' clinical, histopathological and mutational characteristics in patients with high-grade glioma. Subjects and methods: A descriptive study was conducted on 52 high-grade glioma patients who met the research criteria at Vietnam National Cancer Hospital (Tan Trieu campus) from 1st January 2019 to 12th December 2020. Results: The mean age of the study patients was 45.2 ± 14.4; men accounted for the majority (61.5%). The main reason for the patient's admission was headache, hemiplegia, epilepsy... The average Karnofski score of the patient was 68.5 ± 14.7 points. The results of IDH gene mutation show that patients with grade III GCC have a higher positive rate than grade IV, P53 gene mutations occur mainly in grade IV GCC patients, MGMT methylation occurs on 57% of study patients. Conclusion: High-grade glioma is common in men aged over 40. Common clinical symptoms are headache, hemiplegia, and epilepsy. IDH gene mutations are seen in grade III gliomas, P53 gene mutations are common in grade IV gliomas.
* Keywords: High-grade glioma; IDH gene mutation; P53 gene mutation; MGMT methylation.
Vietnam Military Medical University
Title: Study on some clinical features, histopathology and mutations in IDH, P53 genes, mgmt methylation in patients with high-grade glioma
Description:
Objectives: To describe some genes' clinical, histopathological and mutational characteristics in patients with high-grade glioma.
Subjects and methods: A descriptive study was conducted on 52 high-grade glioma patients who met the research criteria at Vietnam National Cancer Hospital (Tan Trieu campus) from 1st January 2019 to 12th December 2020.
Results: The mean age of the study patients was 45.
2 ± 14.
4; men accounted for the majority (61.
5%).
The main reason for the patient's admission was headache, hemiplegia, epilepsy.
The average Karnofski score of the patient was 68.
5 ± 14.
7 points.
The results of IDH gene mutation show that patients with grade III GCC have a higher positive rate than grade IV, P53 gene mutations occur mainly in grade IV GCC patients, MGMT methylation occurs on 57% of study patients.
Conclusion: High-grade glioma is common in men aged over 40.
Common clinical symptoms are headache, hemiplegia, and epilepsy.
IDH gene mutations are seen in grade III gliomas, P53 gene mutations are common in grade IV gliomas.
* Keywords: High-grade glioma; IDH gene mutation; P53 gene mutation; MGMT methylation.
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