Case Report of Acromegaly Secondary to Pituitary Macroadenoma

Acromegaly is a rare endocrine disorder resulting from chronic excess secretion of growth hormone (GH), usually caused by pituitary adenomas. This condition leads to elevated levels of insulin-like growth factor 1 (IGF-1), resulting in characteristic somatic and metabolic complications. We report the case of a 46-year-old female patient with a long-standing history of type 2 diabetes mellitus, who presented with clinical signs suggestive of acromegaly, including prognathism, macroglossia, and enlargement of hands and feet. Laboratory evaluation revealed elevated serum GH and IGF-1 levels, with unsuppressed GH after oral glucose tolerance test. Cranial imaging demonstrated a solid pituitary macroadenoma compressing the optic chiasm. The patient was scheduled for transsphenoidal resection as the first-line treatment. Discussion: This case highlights the importance of early clinical suspicion and diagnostic confirmation using ACROSCORE, hormonal evaluation, and imaging. Management decisions were guided by tumor size, biochemical activity, and current clinical guidelines. Multidisciplinary follow-up is essential to assess for remission, monitor comorbidities, and reduce long-term mortality risk. Conclusion This report underscores the relevance of timely diagnosis and personalized management in acromegaly. Surgical resection remains the cornerstone of treatment in resectable macroadenomas, with medical therapy reserved for persistent or recurrent disease.