Phyllodic tumors of the breast: Frequency and anatomo-histoclinical aspects at Conakry University Teaching Hospital (CHU). Guinea

Objectives: Calculate the frequency of phyllodes tumors of the breast, describe the epidemiological profile and describe the anatomo-histoclinical aspects of phyllodes tumors of the breast at the Conakry University Teaching Hospital. Methodology: This was a retrospective descriptive type study lasting 10 years, from January 1, 2008 to December 31, 2018. It concerned all cases of breast lesions, the parts that were examined in the anatomo-pathological laboratory. All cases of mammary tumours were included for the diagnosis of phyllodes tumor which was histologically confirmed. All cases of breast lesions for which the diagnosis was histologically ruled out were excluded. We carried out an exhaustive examination of the data available in the registers of the anatomo-pathologies service of the Conakry University Teaching Hospital. . The limitations or constraints of the study were the absence of certain information on the pathological examination request forms and the absence of an immunohistochemical study. Results: The frequency of phyllodes tumors was 02.72% (n = 22) among benign and malignant breast pathologies (n = 807) and 1.65% among those of genital and breast pathologies (n = 1334). The epidemiologic profile was that of a woman in the age group 50-59 (27.27%), nulliparous (45.45%). Inflammation was the main reason for consultation (100%). The main presumptive clinical diagnosis was benign tumor (54.54%). Lumpectomy was the main surgical procedure (36.36%) followed by excised biopsies (27.27%). Cases of phyllodes with a consistency firm were the most observed (50%) followed by cases with associated consistency 6 cases (27.27%). Phyllodes tumours without rearrangements represented (63.63%) followed by cases with associated rearrangements (13.63%). Grade I constituted the majority of the histological grade found (54.54%) followed by grade II (22.73%). Phyllodes tumors with benign behavior constituted the majority of cases observed 17 (77.27%). Tumors resected in a healthy zone were the most represented (72.73%). The histologic types with good prognosis constituted the majority of our diagnosed cases (77.27%). Conclusion: Phyllodes tumours constitute of a particular histological type of fibroepithelial tumours of the breast. They constitute a predominantly benign tumor, its malignant forms consist of high-grade sarcomas, often with a poor prognosis. They affect all ages, but especially women between the third and fifth decade. Their diagnosis is exclusively histological, which makes it possible to assess to their behavior, grade and histological prognosis